Publication Name	World Journal of Hepatology
Manuscript ID	67756
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Pediatric non-cirrhotic portal hypertension: Endoscopic outcome and perspectives from developing nations
Manuscript Source	Invited Manuscript
All Author List	Moinak Sen Sarma and Jayendra Seetharaman
Funding Agency and Grant Number
Corresponding Author	Moinak Sen Sarma, MD, Assistant Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Raebereli Road, Lucknow 226014, Uttar Pradesh, India. mmoinaksen@gmail.com
Key Words	Extrahepatic portal vein obstruction; Non-cirrhotic portal fibrosis; Portosystemic shunt surgery; Congenital hepatic fibrosis
Core Tip	The review discusses the natural history, endoscopic outcome, and management of non-cirrhotic causes of portal hypertension in children, especially in resource constraint developing nations. Extrahepatic portal vein obstruction is the most common cause of portal hypertension in developing countries. Endoscopic variceal ligation and sclerotherapy effectively eradicate the esophageal varices. Other complications require shunt surgery that ultimately reverses portal hypertension. Non-cirrhotic portal fibrosis has favourable outcomes in terms of variceal bleeding and mortality. Isolated congenital hepatic fibrosis (CHF) has a relatively good outcome. Liver transplantation is required when CHF is associated with Caroli’s disease, recurrent cholangitis, and decompensation. The presence of significant renal disease requires combined liver and kidney transplantation.
Citation	Sarma MS, Seetharaman J. Pediatric non-cirrhotic portal hypertension: Endoscopic outcome and perspectives from developing nations. World J Hepatol 2021; 13(10): 1269-1288

Received	2021-04-30 19:22
Peer-Review Started	2021-04-30 19:23
To Make the First Decision
Return for Revision	2021-06-15 21:50
Revised	2021-06-27 18:53
Second Decision	2021-09-17 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-19 09:04
Articles in Press	2021-09-19 09:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-20 05:47

ISSN	1948-5182 (online)
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