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10/15/2021 8:59:56 AM | Browse: 165 | Download: 217
Publication Name World Journal of Stem Cells
Manuscript ID 67900
Country/Territory Italy
Category Physiology
Manuscript Type Basic Study
Article Title ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells
Manuscript Source Invited Manuscript
All Author List Giuliana Mannino, Martina Cristaldi, Giovanni Giurdanella, Rosario Emanuele Perrotta, Debora Lo Furno, Rosario Giuffrida and Dario Rusciano
Funding Agency and Grant Number
Funding Agency Grant Number
University of Catania, Italy, “Piano Triennale per la Ricerca 2020-2022–Grant PIACERI, project “NanoRet”
Corresponding Author Debora Lo Furno, PhD, Assistant Professor, Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, Catania 95123, CT, Italy. lofurno@unict.it
Key Words Adipose-derived mesenchymal stem cells; Retinal pigment epithelium; Neural markers; Neural differentiation; Retina damage; Cell-based medicine
Core Tip Neural-like differentiation of adipose-derived stem cells (ASCs) was tested using a conditioned medium from ARPE-19 cells, a cell line derived from human retinal pigment epithelium. Following this treatment, the expression of typical glial and neuronal markers increased in a time-dependent manner. Neural-like differentiated ASCs may represent a valuable tool for cell-based therapeutic approaches in the field of regenerative medicine for the treatment of eye diseases.
Citation Mannino G, Cristaldi M, Giurdanella G, Perrotta RE, Lo Furno D, Giuffrida R, Rusciano D. ARPE-19 conditioned medium promotes neural differentiation of adipose-derived mesenchymal stem cells. World J Stem Cells 2021; 13(11): 1783-1796
Received
2021-05-05 16:02
Peer-Review Started
2021-05-05 16:03
To Make the First Decision
Return for Revision
2021-06-23 14:50
Revised
2021-06-25 11:27
Second Decision
2021-10-15 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-15 08:59
Articles in Press
2021-10-15 08:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-29 03:52
Typeset the Manuscript
2021-11-22 05:02
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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