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10/15/2021 8:53:52 AM | Browse: 103 | Download: 128
Publication Name World Journal of Immunology
Manuscript ID 68033
Country/Territory Bulgaria
Category Transplantation
Manuscript Type Opinion Review
Article Title Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant
Manuscript Source Unsolicited Manuscript
All Author List Milena Peruhova, Monika Peshevska-Sekulovska and Tsvetelina Velikova
Funding Agency and Grant Number
Corresponding Author Milena Peruhova, MD, Assistant Professor, Chief Doctor, Department of Gastroenterology, University Hospital Lozenetz, Kozyak 1 str., Sofia 1407, Bulgaria. mperuhova@gmail.com
Key Words Liver transplantation; De novo malignancy; Immunosuppressive therapy; Calcineurin inhibitors; Tacrolimus; Cyclosporine; Microbiome; Carcinogenesis; Immune tolerance
Core Tip It was estimated that liver transplant recipients have a higher risk of developing de novo malignancy (DNM) compared to the general population. Immunosuppressive (IS) therapy used after liver transplantation (LT) is one of the substantial risk factors for the development of DNM. Tumorigenesis and tumor growth in LT patients are linked with the length of IS therapy's administration and intensity. Recent data showed that the microbiota could significantly affect the survival and acceptance of transplanted allographs. This once again indicates the incredibly complex interaction between the immune system and microbiome in the settings of LT and raises the possible strategies to induce immunotolerance and reduce the complications such as DNM.
Citation Peruhova M, Peshevska-Sekulovska M, Velikova T. Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant. World J Immunol 2021; 11(2): 11-16
Received
2021-05-09 20:09
Peer-Review Started
2021-05-09 20:12
To Make the First Decision
Return for Revision
2021-07-27 06:29
Revised
2021-08-16 12:28
Second Decision
2021-10-15 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-15 08:53
Articles in Press
2021-10-15 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-30 23:41
Typeset the Manuscript
2021-10-26 07:03
ISSN 2219-2824 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 05533165, and 05190007
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Donna Fox
Production Editor Ji-Hong Liu
Responsible Production Editor Ji-Hong Liu
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJI-11-11.pdf
Full Article (Word) WJI-11-11.docx
Manuscript File 68033_Auto_Edited-JRF-FilipodiaCL.docx
Answering Reviewers 68033-Answering reviewers.pdf
Audio Core Tip 68033-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 68033-Conflict-of-interest statement.pdf
Copyright License Agreement 68033-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 68033-Language certificate.pdf
Peer-review Report 68033-Peer-review(s).pdf
Scientific Misconduct Check 68033-Bing-Gong ZM-1.png
Scientific Misconduct Check 68033-Bing-Fan JR-2.png
Scientific Editor Work List 68033-Scientific editor work list.pdf