Publication Name	World Journal of Stem Cells
Manuscript ID	68148
Country	Thailand

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Age and genotype dependent erythropoietin protection in COVID-19
Manuscript Source	Invited Manuscript
All Author List	Konstantinos I Papadopoulos, Warachaya Sutheesophon, Somjate Manipalviratn and Tar-Choon Aw
Funding Agency and Grant Number
Corresponding Author	Konstantinos I Papadopoulos, MD, PhD, Chairman, Chief Doctor, Director, Department of Research and Development, THAI StemLife, 566/3 Soi Ramkhamhaeng 39 (Thepleela 1), Prachaouthit Road, Wangthonglang, Bangkok 10310, Thailand. kostas@thaistemlife.co.th
Key Words	Erythropoietin; Angiotensin converting enzyme; Angiotensin II; Hemoglobinopathy; Malaria; Coronavirus disease 2019; Fibroblast growth factor 23
Core Tip	Erythropoietin (EPO) appears to mediate an ancestral neuroprotective innate immune response mechanism mitigating tissue injury and pathogen invasion at an early age. Age-dependent but anemia-unrelated EPO elevation has been reported in conditions that threaten the young brain such as prematurity, incipient kernicterus, and malaria. Malaria protective genetic determinants such as the angiotensin converting enzyme (ACE) D allele and the thalassemias can raise EPO and extend their protection against coronavirus disease 2019 in an age-dependent manner but could turn detrimental in genetically predisposed adults. ACE2 could represent a “bait” for severe acute respiratory syndrome coronavirus-2 to induce ACE/ACE2 imbalance and angiotensin II engendered protective EPO increase at a young age irrespective of genetic predisposition.
Citation	Papadopoulos KI, Sutheesophon W, Manipalviratn S, Aw T. Age and genotype dependent erythropoietin protection in COVID-19. World J Stem Cells 2021; 13(10): 1513-1529

Received	2021-05-17 00:42
Peer-Review Started	2021-05-17 00:45
To Make the First Decision
Return for Revision	2021-06-16 03:47
Revised	2021-06-23 06:50
Second Decision	2021-09-17 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-19 09:06
Articles in Press	2021-09-19 09:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-22 09:32

ISSN	1948-0210 (online)
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