Publication Name	World Journal of Gastroenterology
Manuscript ID	68241
Country	China

Category	Immunology
Manuscript Type	Basic Study
Article Title	Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation
Manuscript Source	Unsolicited Manuscript
All Author List	Chang-Ju Zhu, Wan-Guang Yang, De-Jian Li, Yao-Dong Song, San-Yang Chen, Qiao-Fang Wang, Yan-Na Liu, Yan Zhang, Bo Cheng, Zhong-Wei Wu and Zong-Chao Cui
Funding Agency and Grant Number	Funding Agency Grant Number Key Research Projects of Henan Higher Education Institutions 20A320064
Corresponding Author	Chang-Ju Zhu, PhD, Academic Fellow, Chief Doctor, Henan Medical Key Laboratory of Emergency and Trauma Research, The First Affiliated Hospital of Zhengzhou University, No. 1 Eastern Jianshe Road, Zhengzhou 450052, Henan Province, China. zhuchangju98@163.com
Key Words	Severe acute pancreatitis; Acute lung injury; Calycosin; Mouse model; High-mobility group box 1; Nuclear factor-kappa B
Core Tip	In this study, we showed that Calycosin protects mice against L-argine-induced severe acute pancreatitis (SAP) and associated acute lung injury (ALI) by attenuating local and systemic inflammatory response via inhibition of high mobility group box 1 (HGMB1) and nuclear factor-kappa B signaling pathway. Suppression of HMGB1 expression is a potential target for the treatment of SAP-ALI.
Citation	Zhu CJ, Yang WG, Li DJ, Song YD, Chen SY, Wang QF, Liu YN, Zhang Y, Cheng B, Wu ZW, Cui ZC. Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1 - induced inflammation. World J Gastroenterol 2021; 27(44): 7669-7686

Received	2021-05-17 06:21
Peer-Review Started	2021-05-17 06:26
To Make the First Decision
Return for Revision	2021-06-26 03:09
Revised	2021-07-09 23:15
Second Decision	2021-09-09 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-10 09:25
Articles in Press	2021-09-10 09:25
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-09 10:38
Typeset the Manuscript	2021-11-24 03:11

ISSN	1007-9327 (print) and 2219-2840 (online)
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