Publication Name	World Journal of Stem Cells
Manuscript ID	68279
Country	Serbia

Category	Cell Biology
Manuscript Type	Review
Article Title	Dental mesenchymal stromal/stem cells in different microenvironments—implications in regenerative therapy
Manuscript Source	Invited Manuscript
All Author List	Ivana Okić-Đorđević, Hristina Obradović, Tamara Kukolj, Anđelija Petrović, Slavko Mojsilović, Diana Bugarski and Aleksandra Jauković
Funding Agency and Grant Number
Corresponding Author	Ivana Okić-Đorđević, PhD, Assistant Professor, Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr Subotića 4, PO BOX 102, Belgrade 11129, Serbia. ivana.okic@imi.bg.ac.rs
Key Words	Microenvironment; Dental mesenchymal stem cells; Modulation of regenerative potential; Tissue origin; Hypoxia microenvironment; Inflammatory microenvironment; Clinical application
Core Tip	This review discusses recent advances in comparative analyses of dental mesenchymal stem cell (MSC) regeneration potential. We have summarized the available research evidence concerning the effects of hypoxic and inflammatory microenvironmental factors on dental MSC differentiation capacity. Existing investigations indicate the very important aspect of the recipient microenvironment niche in terms of therapeutic efficacy of transplanted dental MSCs. However, some of the data for the same cell type (especially in hypoxic in vitro conditions) are conflicting, so it is important to point out that the biology of MSCs is not yet fully known, and further research in this area is needed.
Citation	Okić-Đorđević I, Obradović H, Kukolj T, Petrović A, Mojsilović S, Bugarski D, Jauković A. Dental mesenchymal stromal/stem cells in different microenvironments—implications in regenerative therapy. World J Stem Cells 2021; 13(12): 1863-1880

Received	2021-05-17 13:38
Peer-Review Started	2021-05-17 13:43
To Make the First Decision
Return for Revision	2021-06-05 01:33
Revised	2021-06-15 13:18
Second Decision	2021-11-24 03:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-25 02:41
Articles in Press	2021-11-25 02:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-13 09:15

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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