Publication Name	World Journal of Hepatology
Manuscript ID	69046
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for Clostridioides difficile infection
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Jiang, Salil Chowdhury, Bing-Hong Xu, Mohamad Aghaie Meybodi, Konstantinos Damiris, Samanthika Devalaraju and Nikolaos Pyrsopoulos
Funding Agency and Grant Number
Corresponding Author	Nikolaos Pyrsopoulos, FAASLD, AGAF, FACG, MD, PhD, Director, Professor, Department of Medicine, Gastroenterology and Hepatology, Rutgers New Jersey Medical School, 185 S. Orange Avenue, Medical Science Building H-536, Newark, NJ 07101, United States. pyrsopni@njms.rutgers.edu
Key Words	Nonalcoholic fatty liver disease; Clostridioides difficile infection; Gut microbiota; Intestinal complications; Alcoholic liver disease; Viral liver disease
Core Tip	This study demonstrated that patients hospitalized with Clostridioides difficile infection (CDI) and coexisting nonalcoholic fatty liver disease (NAFLD) had more favorable overall outcomes but higher rates of intestinal complications when compared to those with alcoholic liver disease and viral liver disease individually, which suggests altering gut microbiota may play an essential role in the pathogenesis of both CDI and NAFLD. NAFLD-associated metabolic syndrome may contribute significantly to gut dysbiosis and increase risk for CDI and its complications. This study provides potential directions for future prospective clinical research to identify the clinical meaningfulness of interactions between the gut microbiota, gut immunity and systemic inflammation.
Citation	Jiang Y, Chowdhury S, Xu BH, Meybodi MA, Damiris K, Devalaraju S, Pyrsopoulos N. Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for Clostridioides difficile infection. World J Hepatol 2021; 13(11): 1777-1790

Received	2021-06-14 17:35
Peer-Review Started	2021-06-14 17:40
To Make the First Decision
Return for Revision	2021-07-27 02:32
Revised	2021-08-08 01:47
Second Decision	2021-09-18 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-19 09:03
Articles in Press	2021-09-19 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-11-19 00:42

ISSN	1948-5182 (online)
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