Publication Name	World Journal of Gastroenterology
Manuscript ID	69240
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Letter to the Editor
Article Title	Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model
Manuscript Source	Invited Manuscript
All Author List	Yan-Dong Miao, Jiang-Tao Wang, Xiao-Long Tang and Deng-Hai Mi
Funding Agency and Grant Number
Corresponding Author	Yan-Dong Miao, MD, Doctor, The First Clinical Medical College, Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. miaoyd19@lzu.edu.cn
Key Words	CXCL12; Pancreatic cancer; Splicing isoforms; Bioinformatics analysis; Tumor microenvironment; Pathway
Core Tip	CXCL12 expression was significantly lower in tumor samples than in normal samples. CXCL12 expression was significantly positively associated with the infiltration levels of 12 immune cells, especially T cells, which may encourage further exploration of the effect of CXCL12 in pancreatic ductal adenocarcinoma immunotherapy. In addition, treating pancreatic hTERT-HPNE cells with three diverse CXCL12 isoforms mainly affected the regulation of the epithelial-mesenchymal transition activation pathway.
Citation	Miao YD, Wang JT, Tang XL, Mi DH. Microarray analysis to explore the effect of CXCL12 isoforms in a pancreatic pre-tumor cell model. World J Gastroenterol 2021; 27(47): 8194-8198

Received	2021-06-22 09:49
Peer-Review Started	2021-06-22 09:51
To Make the First Decision
Return for Revision	2021-07-04 05:26
Revised	2021-07-06 16:29
Second Decision	2021-12-01 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-02 01:46
Articles in Press	2021-12-02 01:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-15 02:19

ISSN	1007-9327 (print) and 2219-2840 (online)
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