Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	69357
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Predictive value of serum alpha-fetoprotein for tumor regression after preoperative chemotherapy for rectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Da-Kui Zhang, Jun Qiao, Shao-Xuan Chen, Zhi-Yong Hou and Jian-Zheng Jie
Funding Agency and Grant Number	Funding Agency Grant Number Youth Foundation of China–Japan Friendship Hospital 2019-1-QN-42
Corresponding Author	Jian-Zheng Jie, MD, Doctor, Department of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghuayuan East Street, Beijing 100029, China. dakuizhang2021@126.com
Key Words	Rectal cancer; Preoperative chemotherapy; Alpha-fetoprotein; Predictive value; Tumor
Core Tip	We analyzed 125 patients with locally advanced rectal cancer retrospectively. The patients received 6 cycles of preoperative chemotherapy (mFOLFOX6 every 2 wk). Serum α-fetoprotein (AFP) of 26 patients rose slightly and returned to normal in two months. These patients achieved better tumor regression grade (TRG0-1) than those with normal AFP (61.5% vs 39.4%). Patients with a slight increase of serum AFP showed better tumor regression during preoperative chemotherapy, and were more likely to achieve pathological complete response (30.8% vs 12.1%).
Citation	Zhang DK, Qiao J, Chen SX, Hou ZY, Jie JZ. Predictive value of serum alpha-fetoprotein for tumor regression after preoperative chemotherapy for rectal cancer. World J Gastrointest Oncol 2022; 14(2): 525-532

Received	2021-08-12 08:05
Peer-Review Started	2021-08-12 08:05
To Make the First Decision
Return for Revision	2021-11-08 07:33
Revised	2021-11-20 15:59
Second Decision	2022-01-17 05:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-20 05:14
Articles in Press	2022-01-20 05:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-25 16:50

ISSN	1948-5204 (online)
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