Publication Name	World Journal of Diabetes
Manuscript ID	69391
Country	United States

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response
Manuscript Source	Invited Manuscript
All Author List	Islam N Mohamed, Luling Li, Saifudeen Ismael, Tauheed Ishrat and Azza B El-Remessy
Funding Agency and Grant Number
Corresponding Author	Azza B El-Remessy, PharmD, PhD, Pharmacist, Department of Pharmacy, Doctors Hospital of Augusta, -, Augusta, GA 30907, United States. aelremessy@outlook.com
Key Words	Thioredoxin interacting protein; NOD-like receptor pyrin domain containing 3; Inflammasome; Interleukin 1b; Inflammation; Obesity; High-fat diet; Ischemia; Reperfusion; Oxidative stress
Core Tip	Inflammation has been postulated as the central pathway involved in maintaining homeostasis and in cellular response to insults. High fat diet-induced inflammasome activation have been reported to predispose microvascular diseases including retinopathy, and nonalcoholic fatty liver disease. Inflammation can alter vascular recovery in response to ischemic insult including ischemic retinopathy, stroke and critical limb ischemia. Thioredoxin interacting protein (TXNIP) is required for the activation but not necessarily for expression of NOD-like receptor pyrin domain containing 3-inflammasome resulting in initiation or exacerbation of the disease state. A list of natural antioxidants or repurposed drugs is included to modulate TXNIP expression.
Citation	Mohamed IN, Li L, Ismael S, Ishrat T, El-Remessy AB. Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response. World J Diabetes 2021; 12(12): 1979-1999

Received	2021-06-30 01:17
Peer-Review Started	2021-06-30 01:22
To Make the First Decision
Return for Revision	2021-07-28 05:01
Revised	2021-09-01 02:27
Second Decision	2021-12-01 03:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-12-02 01:48
Articles in Press	2021-12-02 01:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-12-09 07:28

ISSN	1948-9358 (online)
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