Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	69646
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity
Manuscript Source	Invited Manuscript
All Author List	Silvia Bona, Sabrina Alves Fernandes, Andrea C Janz Moreira, Graziella Rodrigues, Elizângela G Schemitt, Fabio Cangeri Di Naso, Cláudio A Marroni and Norma P Marroni
Funding Agency and Grant Number	Funding Agency Grant Number FIPE/Hospital de Clínicas of Porto Alegre
Corresponding Author	Norma P Marroni, PhD, Doctor, Full Professor, Research Scientist, Medical Sciences Program, Universidade Federal do Rio Grande do Sul, Rua José Kanan Aranha 102, Porto Alegre 90040-060, RS, Brazil. nmarroni@terra.com.br
Key Words	Liver injury; Cell damage; Antioxidant; Melatonin; Carbon tetrachloride
Core Tip	Liver cirrhosis is a chronic condition of the liver that is characterized by inflammation, steatosis, and formation of fibrotic tissue that impair liver function. Several studies have demonstrated the relationship between oxidative stress and the development of different diseases. As oxidative stress can damage lipids, proteins, and DNA, causing changes in cell homeostasis, it is important to study therapeutic substances that can minimize or delay the effects of the disease. Hepatotoxic drugs are commonly used as an experimental model to assess different stages of liver disease. Melatonin was used in this work as a therapeutic strategy and showed hepatoprotective action in a chronic hepatotoxicity model.
Citation	Bona S, Fernandes SA, Moreira ACJ, Rodrigues G, Schemitt EG, Di Naso FC, Marroni CA, Marroni NP. Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity. World J Gastrointest Pharmacol Ther 2022; 13(2) 11-22

Received	2021-07-07 17:19
Peer-Review Started	2021-07-07 17:25
To Make the First Decision
Return for Revision	2021-10-05 00:15
Revised	2021-10-18 03:09
Second Decision	2022-01-18 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-20 05:19
Articles in Press	2022-01-20 05:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-04 11:21
Typeset the Manuscript	2022-02-25 01:13

ISSN	2150-5349 (online)
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