Publication Name	World Journal of Clinical Cases
Manuscript ID	69713
Country	South Korea

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data
Manuscript Source	Unsolicited Manuscript
All Author List	Hong Ki Min, Se Hee Kim, Jong Han Choi, Kyomin Choi, Hae-Rim Kim and Sang-Heon Lee
Funding Agency and Grant Number	Funding Agency Grant Number Konkuk University Medical Center Research Grant 2020
Corresponding Author	Sang-Heon Lee, MD, Professor, Division of Rheumatology, Department of Internal Medicine, Konkuk University School of Medicine, 120 Neung-dong Ro, Gwangjin-gu, Seoul KS013, South Korea. shlee@kuh.ac.kr
Key Words	Diabetes mellitus; Neuropathies; Hydroxymethylglutaryl-CoA reductase inhibitors; Metformin
Core Tip	Diabetic neuropathy is one of the most common chronic complication in patients with type 2 diabetes mellitus (T2DM). Statin is commonly used lipid lowering agents in patients with T2DM, and metformin is background medication for T2DM. In some observational studies, the statin and metformin were associated with increased risk of neuropathy. In present study using Korean Health Insurance Review and Assessment national patient sample data, the use of statin was associated with increased risk of diabetic neuropathy occurrence, whereas metformin use showed negative association with diabetic neuropathy.
Citation	Min HK, Lee SH, Choi JH, Choi K, Kim HR, Lee SH. Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data. World J Clin Cases 2021; 9(33): 10198-10207

Received	2021-07-09 10:37
Peer-Review Started	2021-07-09 10:42
To Make the First Decision
Return for Revision	2021-08-09 03:16
Revised	2021-08-09 07:01
Second Decision	2021-09-09 03:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-10 09:09
Articles in Press	2021-09-10 09:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-23 03:22
Typeset the Manuscript	2021-11-15 04:11

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com