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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 69856
Country/Territory United States
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences
Manuscript Source Unsolicited Manuscript
All Author List Sofia C Tortora, Vimal M Bodiwala, Andrew Quinn, Laura A Martello and Shivakumar Vignesh
Funding Agency and Grant Number
Corresponding Author Shivakumar Vignesh, AGAF, FACG, FASGE, MD, Associate Professor, Department of Medicine and Division of Gastroenterology & Hepatology, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Brooklyn, NY 11203, United States. vignesh185@gmail.com
Key Words Colorectal cancer; Oral microbiome; Gut microbiome; Hallmarks of cancer; Racial/ethnic microbial diversity
Core Tip In this review, we describe oral and gut microbiome associated with colorectal (CRC) carcinogenesis in relation to the “hallmarks of cancer” and microbial diversity and abundance between races/ethnicities. CRC patients showed increased levels of Bacteroides, Prevotella, Escherichia coli, enterotoxigenic Bacteroides fragilis, Streptococcus gallolyticus, Enterococcus faecalis, Fusobacterium nucleatum (F. nucleatum) and Clostridium difficile. Higher levels of Bacteroides, F. nucleatum and Enterobacter species have been found in African American (AA) compared to Caucasian American (CA) CRC patients. Also, AA patients had decreased microbial diversity compared to CA patients. Periodontal-associated bacteria, Fusobacterium, Prevotella, Bacteroides and Porphyromonas, have been found in CRC tissues and in feces of CRC patients.
Citation Tortora SC, Bodiwala VM, Quinn A, Martello LA, Vignesh S. Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences. World J Gastrointest Oncol 2022; In press
Received
2021-07-13 21:30
Peer-Review Started
2021-07-13 21:34
To Make the First Decision
Return for Revision
2021-07-29 17:55
Revised
2021-08-26 19:38
Second Decision
2022-01-13 05:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-14 06:29
Articles in Press
2022-01-14 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ping Yan
Reviewer Code 05469117, 05665395, and 03027040
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 69856_Auto_Edited.docx
Answering Reviewers 69856-Answering reviewers.pdf
Audio Core Tip 69856-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 69856-Conflict-of-interest statement.pdf
Copyright License Agreement 69856-Copyright license agreement.pdf
Peer-review Report 69856-Peer-review(s).pdf
Scientific Misconduct Check 69856-Bing-Yan JP-2.jpg
Scientific Editor Work List 69856-Scientific editor work list.pdf