Publication Name	World Journal of Hepatology
Manuscript ID	69958
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Development of the nervous system in mouse liver
Manuscript Source	Unsolicited Manuscript
All Author List	Naoto Koike, Tomomi Tadokoro, Yasuharu Ueno, Satoshi Okamoto, Tatsuya Kobayashi, Soichiro Murata and Hideki Taniguchi
Funding Agency and Grant Number	Funding Agency Grant Number Grant-in-Aid for scientific research (B) from the Ministry of Education, Culture, Sports and Science and Technology of Japan 18H02874 Grant-in-Aid for scientific research (B) from the Ministry of Education, Culture, Sports and Science and Technology of Japan 21H02991
Corresponding Author	Naoto Koike, MD, PhD, Chief Doctor, Department of Surgery, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura 285-8765, Chiba, Japan. naotk@sis.seirei.or.jp
Key Words	Nervous system; Liver; Portal tract; Hepatic artery; Immunohistochemistry; Tissue engineering
Core Tip	The portal tract (PT) consists of branches of the hepatic artery (HA), portal vein, intrahepatic bile ducts (IHBD), and autonomic nerves. This study evaluated the mouse hepatic nervous system development using immunohistochemistry. Hepatic nerve fibers (NFs) first emerge at the hepatic hilus just before birth and extend toward the periphery with IHBD in the PT after birth. The hepatic NFs associated more frequently with the HA than the IHBD in the PT after birth. The hepatic NFs may play important roles in the morphogenesis and stabilization of the PT during development of the liver.
Citation	Koike N, Tadokoro T, Ueno Y, Okamoto S, Kobayashi T, Murata S, Taniguchi H. Development of the nervous system in mouse liver. World J Hepatol 2022; 14(2): 386-399

Received	2021-07-31 01:38
Peer-Review Started	2021-07-31 01:42
To Make the First Decision
Return for Revision	2021-09-29 10:14
Revised	2021-10-12 08:16
Second Decision	2022-01-17 05:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-20 05:16
Articles in Press	2022-01-20 05:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-14 00:30

ISSN	1948-5182 (online)
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