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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 70078
Country/Territory China
Category Oncology
Manuscript Type Basic Study
Article Title Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways
Manuscript Source Unsolicited Manuscript
All Author List Piao Zheng, Zhen Huang, Dong-Chang Tong, Qing Zhou, Sha Tian, Bo-Wei Chen, Di-Min Ning, Yin-Mei Guo, Wen-Hao Zhu, Yan Long, Wei Xiao, Zhe Deng, Yi-Chen Lei and Xue-Fei Tian
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China (Key Program) U20A20408
National Natural Science Foundation of China (General Program) 82074450
Natural Science Foundation of Hunan Province 2020JJ4066
Hunan Province Research and innovation projects for Postgraduates CX20190541
Hunan Province "domestic first-class cultivation discipline" Integrated Traditional Chinese and Western medicine open fund project 2018ZXYJH03
Hunan University Undergraduate Research Learning and Innovative Experiment Project 201609030114
Corresponding Author Xue-Fei Tian, PhD, Professor, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Yuelu District, Changsha 410208, Hunan , China. 003640@hnucm.edu.cn
Key Words Hepatocellular carcinoma; Frankincense; Myrrh; Network pharmacology; Tumor blood vessels; Multiple signaling pathways
Core Tip Hepatocellular carcinoma (HCC) is a serious threat to human health, and its pathological process is closely related to blood vessels. Currently, powerful targeted drugs for HCC treatment are lacking. The discovery of new drugs is an urgent task. As a complementary and alternative therapy, traditional Chinese medicine has played an increasingly prominent role. This study introduces frankincense and myrrh derived from the classic anticancer Chinese patent medicine Xihuang Pill. Through prediction and verification, the findings confirmed that this frankincense and myrrh treatment targets tumor blood vessels through EGFR-activated PI3K/Akt and MAPK signaling pathways to exert anti-HCC effects. Frankincense and/or myrrh treatment might be a potential anti-HCC drug candidate.
Citation Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF. Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol 2022; In press
Received
2021-07-22 14:46
Peer-Review Started
2021-07-22 14:50
To Make the First Decision
Return for Revision
2021-11-08 07:38
Revised
2021-11-19 04:02
Second Decision
2022-01-13 05:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-14 06:28
Articles in Press
2022-01-14 06:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Han Zhang (Online Science Editor)
Reviewer Code 05424290
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 70078_Auto_Edited.docx
Answering Reviewers 70078-Answering reviewers.pdf
Audio Core Tip 70078-Audio core tip.mp3
Biostatistics Review Certificate 70078-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 70078-Conflict-of-interest statement.pdf
Copyright License Agreement 70078-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 70078-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 70078-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 70078-Language certificate.pdf
Peer-review Report 70078-Peer-review(s).pdf
Scientific Editor Work List 70078-Scientific editor work list.pdf