Publication Name	World Journal of Clinical Cases
Manuscript ID	71571
Country	Slovenia

Category	Oncology
Manuscript Type	Case Report
Article Title	Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Peter Kiraly, Alenka Lavrič Groznik, Nataša Vidovič Valentincic, Polona Jaki Mekjavic, Mojca Urbančič, Janja Ocvirk and Tanja Mesti
Funding Agency and Grant Number
Corresponding Author	Tanja Mesti, PhD, Assistant Professor, Medical oncology, Institute of Oncology Ljubljana, Zaloška 2, Ljubljana 1000, Ljubljana, Slovenia. tmesti@onko-i.si
Key Words	Metastatic melanoma treatment; BRAF/MEK inhibitors; Dabrafenib and trametinib; Ocular adverse effects; Bilateral panuveitis; Case report
Core Tip	The effectiveness of B-Raf proto-oncogene serine/threonine kinase (BRAF)/mitogen-activated protein kinase (MEK) inhibitor therapy in terms of prolonging survival has revolutionized the treatment of metastatic melanoma and other cancers. Consequently, widespread use in several metastatic cancers could be anticipated in the future. Therefore, all possible adverse effects should be described. We report a case of very rare and severe bilateral panuveitis with transient visual loss associated with treatment of metastatic malignant melanoma. The purpose of our case report is to raise awareness of possible severe bilateral panuveitis associated with immune checkpoint inhibitor therapy and to show that ocular symptoms subside with BRAF/MEK inhibitor discontinuation and/or systemic corticosteroids. Further studies should establish guidelines for panuveitis management and evaluate the importance of ophthalmological examination for asymptomatic patients.
Citation	Kiraly P, Groznik AL, Valentincic NV, Mekjavic PJ, Urbančič M, Ocvirk J, Mesti T. Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report. World J Clin Cases 2022; 10(19): 6536-6542

Received	2021-09-13 13:35
Peer-Review Started	2021-09-13 13:36
To Make the First Decision
Return for Revision	2022-01-10 08:56
Revised	2022-01-19 14:12
Second Decision	2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-08 07:08
Articles in Press	2022-05-08 07:08
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-04-29 03:22
Typeset the Manuscript	2022-05-23 02:23

ISSN	2307-8960 (online)
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