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Publication Name World Journal of Clinical Cases
Manuscript ID 71571
Country/Territory Slovenia
Category Oncology
Manuscript Type Case Report
Article Title Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report
Manuscript Source Unsolicited Manuscript
All Author List Peter Kiraly, Alenka Lavrič Groznik, Nataša Vidovič Valentincic, Polona Jaki Mekjavic, Mojca Urbančič, Janja Ocvirk and Tanja Mesti
Funding Agency and Grant Number
Corresponding Author Tanja Mesti, PhD, Assistant Professor, Medical oncology, Institute of Oncology Ljubljana, Zaloška 2, Ljubljana 1000, Ljubljana, Slovenia. tmesti@onko-i.si
Key Words Metastatic melanoma treatment; BRAF/MEK inhibitors; Dabrafenib and trametinib; Ocular adverse effects; Bilateral panuveitis; Case report
Core Tip The effectiveness of B-Raf proto-oncogene serine/threonine kinase (BRAF)/mitogen-activated protein kinase (MEK) inhibitor therapy in terms of prolonging survival has revolutionized the treatment of metastatic melanoma and other cancers. Consequently, widespread use in several metastatic cancers could be anticipated in the future. Therefore, all possible adverse effects should be described. We report a case of very rare and severe bilateral panuveitis with transient visual loss associated with treatment of metastatic malignant melanoma. The purpose of our case report is to raise awareness of possible severe bilateral panuveitis associated with immune checkpoint inhibitor therapy and to show that ocular symptoms subside with BRAF/MEK inhibitor discontinuation and/or systemic corticosteroids. Further studies should establish guidelines for panuveitis management and evaluate the importance of ophthalmological examination for asymptomatic patients.
Citation Kiraly P, Groznik AL, Valentincic NV, Mekjavic PJ, Urbančič M, Ocvirk J, Mesti T. Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis: A case report. World J Clin Cases 2022; In press
Received
2021-09-13 13:35
Peer-Review Started
2021-09-13 13:36
To Make the First Decision
Return for Revision
2022-01-10 08:56
Revised
2022-01-19 14:12
Second Decision
2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-08 07:08
Articles in Press
2022-05-08 07:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-04-29 03:22
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Yan-Xia Xing
Reviewer Code 05123258, and 05315718
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 71571_Auto_Edited-YXX-Wang TQ.docx
Answering Reviewers 71571-Answering reviewers.pdf
Audio Core Tip 71571-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 71571-Conflict-of-interest statement.pdf
Copyright License Agreement 71571-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s) 71571-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 71571-Language certificate.pdf
Peer-review Report 71571-Peer-review(s).pdf
Scientific Misconduct Check 71571-Bing Xing YX-2.png
Scientific Editor Work List 71571-Scientific editor work list.pdf