Publication Name	World Journal of Gastroenterology
Manuscript ID	71974
Country	South Korea

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	How has the disease course of pediatric ulcerative colitis changed throughout the biologics era? A comparison with the IBSEN study
Manuscript Source	Unsolicited Manuscript
All Author List	Yiyoung Kwon, Eun sil Kim, Yon Ho Choe and Mi Jin Kim
Funding Agency and Grant Number
Corresponding Author	Mi Jin Kim, MD, PhD, Associate Professor, Pediatrics, Samsung Medical Center, Ilwon-ro 81, Gangnam-gu, Seoul 06351, South Korea. mijin1217.kim@samsung.com
Key Words	Colitis; Ulcerative; Children; Infliximab; Relapse; Steroid
Core Tip	This was a retrospective study that assessed how the introduction of biological agents has altered the disease course over time in pediatric ulcerative colitis (UC). Endoscopic remission, relapse rate, steroid-free period, and the quality of life of each group were evaluated as outcomes. Clinical course was plotted with the pediatric UC activity index score, and compared to that of the IBSEN study. The incidence of relapse has decreased and the steroid-free period has increased after the introduction of biological agents. The clinical course also showed a different pattern from the IBSEN study.
Citation	Kwon Y, Kim E, Choe YH, Kim MJ. How has the disease course of pediatric ulcerative colitis changed throughout the biologics era? A comparison with the IBSEN study. World J Gastroenterol 2022; 28(28): 3666-3681

Received	2021-09-28 09:29
Peer-Review Started	2021-09-28 09:31
To Make the First Decision
Return for Revision	2021-11-18 20:49
Revised	2021-11-29 09:28
Second Decision	2022-06-29 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-30 22:55
Articles in Press	2022-06-30 22:55
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-25 20:01
Typeset the Manuscript	2022-07-15 06:40

ISSN	1007-9327 (print) and 2219-2840 (online)
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