Publication Name	World Journal of Gastroenterology
Manuscript ID	74090
Country	Argentina

Category	Oncology
Manuscript Type	Review
Article Title	Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanism of chemoresistance
Manuscript Source	Invited Manuscript
All Author List	María Belén Novoa Díaz, María Julia Martín and Claudia Gentili
Funding Agency and Grant Number	Funding Agency Grant Number Agencia Nacional de Promoción Científica y Tecnológica PICT-2013-1441 Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220150100350 Instituto Nacional del Cáncer Asistencia Financiera II, RESOL 493/14 2002-4395-14-1 Instituto Nacional del Cáncer Asistencia Financiera III-2016-2017, RESOL-2016-1006-E-APN-MS 2002-3862-16-1 Universidad Nacional del Sur (PGI), Argentina 24/B230 Universidad Nacional del Sur (PGI), Argentina 24/B303
Corresponding Author	María Julia Martín, PhD, Research Assistant, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)-INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Argentina. julia.martin@uns.edu.ar
Key Words	Colorectal cancer; β-catenin pathway; Tumor stroma; Tumor microenvironment factors; Cancer progression; Drug resistance
Core Tip	Currently, there is a high probability of failure in treatments of advanced stages of colorectal cancer (CRC). For this reason, it is necessary to provide a better understanding of CRC biology in a more global context for the future design of novel therapeutic approaches. The importance of the Wnt/β-catenin signaling pathway and the tumor microenvironment (TME) influence on the progression and chemoresistance of this disease were separately described in several review articles. Therefore, herein we comprehensively analyze the complex mechanisms of CRC chemoresistance triggered by TME factors that impact Wnt/β-catenin signaling.
Citation	Novoa Díaz MB, Martín MJ, Gentili C. Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanism of chemoresistance. World J Gastroenterol 2022; 28(26): 3027-3046

Received	2021-12-21 13:33
Peer-Review Started	2021-12-21 13:35
To Make the First Decision
Return for Revision	2022-03-10 07:44
Revised	2022-04-29 16:57
Second Decision	2022-06-13 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 15:54
Articles in Press	2022-06-20 15:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-07 20:51
Typeset the Manuscript	2022-06-22 06:17

ISSN	1007-9327 (print) and 2219-2840 (online)
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