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6/20/2022 3:54:58 PM | Browse: 51 | Download: 22
Publication Name World Journal of Gastroenterology
Manuscript ID 74090
Country/Territory Argentina
Category Oncology
Manuscript Type Review
Article Title Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanism of chemoresistance
Manuscript Source Invited Manuscript
All Author List María Belén Novoa Díaz, María Julia Martín and Claudia Gentili
Funding Agency and Grant Number
Funding Agency Grant Number
Agencia Nacional de Promoción Científica y Tecnológica PICT-2013-1441
Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220150100350
Instituto Nacional del Cáncer Asistencia Financiera II, RESOL 493/14 2002-4395-14-1
Instituto Nacional del Cáncer Asistencia Financiera III-2016-2017, RESOL-2016-1006-E-APN-MS 2002-3862-16-1
Universidad Nacional del Sur (PGI), Argentina 24/B230
Universidad Nacional del Sur (PGI), Argentina 24/B303
Corresponding Author María Julia Martín, PhD, Research Assistant, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur (UNS)-INBIOSUR (CONICET-UNS), San Juan 670, Bahía Blanca 8000, Argentina. julia.martin@uns.edu.ar
Key Words Colorectal cancer; β-catenin pathway; Tumor stroma; Tumor microenvironment factors; Cancer progression; Drug resistance
Core Tip Currently, there is a high probability of failure in treatments of advanced stages of colorectal cancer (CRC). For this reason, it is necessary to provide a better understanding of CRC biology in a more global context for the future design of novel therapeutic approaches. The importance of the Wnt/β-catenin signaling pathway and the tumor microenvironment (TME) influence on the progression and chemoresistance of this disease were separately described in several review articles. Therefore, herein we comprehensively analyze the complex mechanisms of CRC chemoresistance triggered by TME factors that impact Wnt/β-catenin signaling.
Citation Novoa Díaz MB, Martín MJ, Gentili C. Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway: Providing understanding of the complex mechanism of chemoresistance. World J Gastroenterol 2022; In press
2021-12-21 13:33
Peer-Review Started
2021-12-21 13:35
To Make the First Decision
Return for Revision
2022-03-10 07:44
2022-04-29 16:57
Second Decision
2022-06-13 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-20 15:54
Articles in Press
2022-06-20 15:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-06-07 20:51
Typeset the Manuscript
2022-06-22 06:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 05128663, 05914859, 05224033, 06045450, and 05081392
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor Donna Fox
Production Editor Hua-Ge Yu
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 74090_Auto_Edited_LM.docx
Answering Reviewers 74090-Answering reviewers.pdf
Audio Core Tip 74090-Audio core tip.ogg
Conflict-of-Interest Disclosure Form 74090-Conflict-of-interest statement.pdf
Copyright License Agreement 74090-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74090-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 74090-Language certificate.pdf
Peer-review Report 74090-Peer-review(s).pdf
Scientific Misconduct Check 74090-Bing-Fan JR-2.png
Scientific Editor Work List 74090-Scientific editor work list.pdf