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Publication Name World Journal of Psychiatry
Manuscript ID 74162
Country/Territory United States
Category Psychiatry
Manuscript Type Observational Study
Article Title Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia
Manuscript Source Invited Manuscript
All Author List Mohammad M Khan
Funding Agency and Grant Number
Corresponding Author Mohammad M Khan, PhD, Professor, Laboratory of Translational Neurology and Molecular Psychiatry, Department of Biotechnology, Era's Lucknow Medical College and Hospital, and Faculty of Science, Era University, Sarfarazganj, Hardoi Road, Lucknow 226003, India. mmkhan0@gmail.com
Key Words Schizophrenia; Leptin; Fatty acids; Insulin resistance; Impaired energy expenditure
Core Tip Insulin resistance (IR) and impaired energy expenditure (IEE) are untreatable metabolic comorbidities in schizophrenia. Leptin and fatty acids have profound influence on insulin synthesis, secretion and energy metabolism. Although previous studies have measured plasma leptin and membrane fatty acids in schizophrenia, findings are very heterogeneous, and moreover, no single study has ever measured both plasma leptin and membrane fatty acids together in the same cohort of schizophrenia patients. These studies are crucial not only for analyzing the relationship between leptin and fatty acids in the same cohort of schizophrenia patients, but also for deciphering their role in the development of IR and IEE.
Citation Khan MM. Disrupted leptin-fatty acid biosynthesis is an early manifestation of metabolic abnormalities in schizophrenia. World J Psychiatry 2022; 12(6): 827-842
Received
2021-12-31 11:02
Peer-Review Started
2021-12-31 11:04
To Make the First Decision
Return for Revision
2022-03-13 21:25
Revised
2022-04-03 14:44
Second Decision
2022-05-18 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-23 01:04
Articles in Press
2022-05-23 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-05-27 01:26
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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