Publication Name	World Journal of Diabetes
Manuscript ID	74243
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Prospective Study
Article Title	Relationship of quality of life with adolescent glycolipid metabolism disorder: A cohort study
Manuscript Source	Invited Manuscript
All Author List	Xiao-Hua Liang, Yang-Ling Ren, Xiao-Yue Liang, Jing-Yu Chen, Ping Qu and Xian Tang
Funding Agency and Grant Number	Funding Agency Grant Number Intelligent Medicine Research Project of Chongqing Medical University ZHYX202109 The Major Health Project of Chongqing Science and Technology Bureau CSTC2021jscx-gksb-N0001 Research and Innovation Team of Chongqing Medical University W0088 Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau 2020MSXM062 National Key Research and Development Project of the Ministry of Science and Technology of the People's Republic of China 2017YFC0211705 Young Scientists Fund Program of the National Natural Science Foundation of China 81502826
Corresponding Author	Xiao-Hua Liang, MD, PhD, Associate Research Scientist, Department of Clinical Epidemiology and Biostatistics, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Health and Nutrition, No. 136 2nd Street, Yuzhong District, Chongqing 400016, China. xiaohualiang@hospital.cqmu.edu.cn
Key Words	Quality of life; Insulin resistance; Lipids; Metabolic abnormality
Core Tip	Persistent abnormalities of glucose and lipid metabolism in childhood have a well-established association with adulthood cardiovascular diseases. Previous conclusions about the association between quality of life (QoL) and glycolipid metabolism disorder were almost all based on adults with type 2 diabetes or dyslipidaemia, whereas there is limited evidence for the association between QoL and glycolipid metabolism disorder in healthy children and adolescents. This study found that a poor QoL score was associated with increased insulin, triglyceride, and IR levels, and the association was more significant in males than in females. In addition, seven domains, four factors, and total QoL score were negatively associated with abnormalities in glucose and lipid metabolism. Measures to improve the QoL of adolescents are essential to reduce the prevalence of glycolipid metabolism disorder.
Citation	Liang XH, Ren YL, Liang XY, Chen JY, Qu P, Tang X. Relationship of quality of life with adolescent glycolipid metabolism disorder: A cohort study. World J Diabetes 2022; 13(7): 566-580

Received	2021-12-20 00:19
Peer-Review Started	2021-12-20 00:22
To Make the First Decision
Return for Revision	2022-04-18 00:53
Revised	2022-04-29 09:24
Second Decision	2022-06-15 02:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 21:59
Articles in Press	2022-06-20 21:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-13 02:03
Typeset the Manuscript	2022-07-05 14:24

ISSN	1948-9358 (online)
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