Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	74252
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Wang, Meng-Nan Guo, Ning Li, De-Quan Pang and Jing-Hua Wu
Funding Agency and Grant Number	Funding Agency Grant Number High-End Talent Funding Project in Hebei Province A202003005 Hebei Provincial Health Commission Office G2019074 Natural Science Foundation of Hebei Province H2019209355
Corresponding Author	Jing-Hua Wu, MD, PhD, Chief Technician, Professor, Department of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, No. 1 Hetai Road, Lunan District, Tangshan 063000, Hebei Province, China. tswujinghua@163.com
Key Words	Glutamine; Mitochondrial damage; CD8+ T cells; T cell function; Hepatocellular carcinoma
Core Tip	This study aimed to investigate whether and how glutamine metabolism affects the function of infiltrating CD8+ T cells in hepatocellular carcinoma. Experimental validation was performed by using liver cancer tissues and cell lines. We discovered that glutamine deprivation impaired the function of infiltrating CD8+ T cells in hepatocellular carcinoma through the mitochondrial damage and apoptotic pathways.
Citation	Wang W, Guo MN, Li N, Pang DQ, Wu JH. Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis. World J Gastrointest Oncol 2022; 14(6): 1124-1140

Received	2021-12-18 06:20
Peer-Review Started	2021-12-18 06:22
To Make the First Decision
Return for Revision	2022-04-17 19:18
Revised	2022-04-22 16:06
Second Decision	2022-05-20 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-23 00:45
Articles in Press	2022-05-23 00:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-19 12:04
Typeset the Manuscript	2022-06-07 03:20

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com