Publication Name	World Journal of Hepatology
Manuscript ID	74526
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Natural history and management of liver dysfunction in lysosomal storage disorders
Manuscript Source	Invited Manuscript
All Author List	Moinak Sen Sarma and Parijat Ram Tripathi
Funding Agency and Grant Number
Corresponding Author	Moinak Sen Sarma, MD, Associate Professor, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow 226014, India. moinaksen@gmail.com
Key Words	Lysosomal; Gaucher; Niemann-Pick; Wolman; Cholesteryl ester; Children
Core Tip	Lysosomal storage disorders have a multisystem involvement. Gaucher disease, Niemann-Pick disease, and lysosomal acid lipase deficiency (Wolman disease and cholesteryl ester storage disorder) may have predominant liver dysfunction. Those with neonatal-onset, predominant severe extrahepatic and multi-systemic presentations often have challenging outcomes. Enzyme replacement therapy and liver transplantation are encouraged in select situations. Genetic tests and counseling are important aspects of management.
Citation	Sen Sarma M, Tripathi PR. Natural history and management of liver dysfunction in lysosomal storage disorders. World J Hepatol 2022; 14(10): 1844-1861

Received	2021-12-27 08:20
Peer-Review Started	2021-12-27 08:21
To Make the First Decision
Return for Revision	2022-03-07 03:13
Revised	2022-04-21 04:03
Second Decision	2022-09-19 03:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-21 21:43
Articles in Press	2022-09-21 21:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-21 05:31
Typeset the Manuscript	2022-10-24 04:08

ISSN	1948-5182 (online)
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