Publication Name	World Journal of Hepatology
Manuscript ID	74702
Country	Spain

Category	Transplantation
Manuscript Type	Retrospective Study
Article Title	DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Leonardo Lorente, Sergio T Rodriguez, Pablo Sanz, Agustín F González-Rivero, Antonia Pérez-Cejas, Javier Padilla, Dácil Díaz, Antonio González, María M Martín, Alejandro Jiménez, Purificación Cerro, Julián Portero and Manuel A Barrera
Funding Agency and Grant Number
Corresponding Author	Leonardo Lorente, MD, PhD, Attending Doctor, Medical Assistant, Department of Intensive Care, Hospital Universitario de Canarias, Ofra, s/n., La Laguna 38320, Tenerife, Spain. lorentemartin@msn.com
Key Words	DNA oxidative damage; Hepatocellular carcinoma; Liver transplantation; Mortality; Oxidized guanine species
Core Tip	There is not published data about the potential use of DNA and RNA oxidative damage to predict prognosis of patients with hepatocellular carcinoma (HCC) underwent to liver transplantation (LT). In this retrospective study were measured serum levels of the three oxidized guanine species (OGS) before LT in 114 patients. One-year survivor patients showed lower serum OGS levels than non-survivor patients (P = 0.01). These preliminary results could induce studies to clarify the potential role of oxidative damage in prognosis of LT patients due to HCC and to explore the use of antioxidants agents to reduce oxidative stress in those patients.
Citation	Lorente L, Rodriguez ST, Sanz P, González-Rivero AF, Pérez-Cejas A, Padilla J, Díaz D, González A, Martín MM, Jiménez A, Cerro P, Portero J, Barrera MA. DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation. World J Hepatol 2022; 14(6): 1182-1189

Received	2022-01-14 18:11
Peer-Review Started	2022-01-14 18:12
To Make the First Decision
Return for Revision	2022-03-24 09:30
Revised	2022-03-28 18:25
Second Decision	2022-05-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-23 00:39
Articles in Press	2022-05-23 00:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-14 14:23
Typeset the Manuscript	2022-05-26 06:38

ISSN	1948-5182 (online)
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