Publication Name	World Journal of Gastroenterology
Manuscript ID	74848
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Rebuilding trust in proton pump inhibitor therapy
Manuscript Source	Invited Manuscript
All Author List	Alla Turshudzhyan, Sonia Samuel, Angela Tawfik and Micheal Tadros
Funding Agency and Grant Number
Corresponding Author	Micheal Tadros, FACG, MD, Associate Professor, Department of Gastroenterology and Hepatology, Albany Medical College, 49 New Scotland Ave, Albany, NY 12208, United States. tadrosm1@amc.edu
Key Words	Proton pump inhibitor; Side-effects; Gastro-esophageal reflux disease; Therapy
Core Tip	Proton pump inhibitor (PPI) therapy is a cornerstone therapy for acid-related diseases. Its clinical success can be attributed to anti-secretory properties superior to any prior agents and seemingly low side-effects profile. As more patients were started and continued PPI therapy long-term, some studies began reporting side-effects associated with this therapy. Concerns over risks associated with PPI use grew over the last couple of years among both patients and providers. We hope to bring awareness to the current guidelines and the evidence behind the reported side-effects as better understanding of this evidence can improve medical practice. Both patients and providers should have all the evidence at hand when discussing initiation or continuation of PPI therapy.
Citation	Turshudzhyan A, Samuel S, Tawfik A, Tadros M. Rebuilding trust in proton pump inhibitor therapy. World J Gastroenterol 2022; 28(24): 2667-2679

Received	2022-01-10 23:00
Peer-Review Started	2022-01-10 23:02
To Make the First Decision
Return for Revision	2022-03-08 21:27
Revised	2022-03-15 01:17
Second Decision	2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-08 07:15
Articles in Press	2022-05-08 07:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-10 08:14

ISSN	1007-9327 (print) and 2219-2840 (online)
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