Publication Name	World Journal of Neurology
Manuscript ID	74913
Country/Territory	India

Category	Neurosciences
Manuscript Type	Minireviews
Article Title	Role of cell-free DNA for predicting incidence and outcome of patients with ischemic stroke
Manuscript Source	Unsolicited Manuscript
All Author List	Nusrath Fathima, Sandhya Manorenj, Sandeep Kumar Vishwakarma and Aleem Ahmed Khan
Funding Agency and Grant Number
Corresponding Author	Aleem Ahmed Khan, PhD, N/A, Central Laboratory for Stem Cell Research and Translational Medicine, Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, DMRL X Road, Hyderabad 500058, Telangana, India. aleem_a_khan@rediffmail.com
Key Words	Ischemic stroke; Mitochondria; Circulating cell-free DNA; Plasma nucleic acid; Mortality
Core Tip	Early and accurate diagnosis of ischemic stroke is critical to achieve favorable clinical outcome. Cell-free DNA can be used as a useful biomarker for early diagnosis and prognosis of ischemic stroke for saving time and increasing the likelihood of successful intervention. Discriminative quantification of cell free mitochondrial DNA instead of overall circulating DNA may provide more significant value for identifying real-time host response. The future practical adoption of this strategy may be aided by reliable and standardized quantification of cell-free mitochondrial DNAs in ischemic stroke patients to design more effective diagnosis, prognosis and therapeutic strategies.
Citation	Fathima N, Manorenj S, Vishwakarma SK, Khan AA. Role of cell-free DNA for predicting incidence and outcome of patients with ischemic stroke. World J Neurol 2022; In press

Received	2022-01-11 07:23
Peer-Review Started	2022-01-11 07:24
To Make the First Decision
Return for Revision	2022-05-31 02:35
Revised	2022-06-11 02:04
Second Decision	2022-07-25 07:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-31 20:48
Articles in Press	2022-07-31 20:48
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ISSN	2218-6212 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Assistant Editor	Assistant Editor
Science Editor	Chen-Chen Gao
Reviewer Code	02439752, and 06220599
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Company Chief Editor	Lian-Sheng Ma
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Proofing Editor-in-Chief	Lian-Sheng Ma

Manuscript File	74913_Auto_Edited-LS.docx
Answering Reviewers	74913-Answering reviewers.pdf
Audio Core Tip	74913-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	74913-Conflict-of-interest statement.pdf
Copyright License Agreement	74913-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	74913-Language certificate.pdf
Peer-review Report	74913-Peer-review(s).pdf
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Scientific Editor Work List	74913-Scientific editor work list.pdf