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5/8/2022 7:20:35 AM | Browse: 37 | Download: 31
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 75089
Country/Territory Egypt
Category Oncology
Manuscript Type Review
Article Title Fibrolamellar hepatocellular carcinoma: A rare but unpleasant event
Manuscript Source Invited Manuscript
All Author List Walaa Abdelhamed and Mohamed El-Kassas
Funding Agency and Grant Number
Corresponding Author Mohamed El-Kassas, MD, Full Professor, Department of Endemic Medicine, Faculty of Medicine, Helwan University, Helwan, Cairo 11795, Egypt. m_elkassas@yahoo.com
Key Words Fibrolamellar carcinoma; Hepatocellular carcinoma; Hepatitis; Cirrhosis; Viral hepatitis infection
Core Tip Fibrolamellar carcinoma (FLC) is a rare liver cancer that displays unique features in behavior and clinical findings from conventional hepatocellular carcinoma (HCC). No certain underlying trigger is detected in FLC. Alpha-fetoprotein levels are normal, unlike in traditional HCC. Surgery (resection/liver transplantation) is the current mainstay of treatment and remains the only curative option. FLCs have been less chemo-responsive than the conventional HCC. Controlled trials evaluating checkpoint inhibitors in FLC are lacking. In this review, we collect and summarize current evidence and clinical experience of conversion therapy, highlight remaining problems and challenges for further research.
Citation Abdelhamed W, El-Kassas M. Fibrolamellar hepatocellular carcinoma: A rare but unpleasant event. World J Gastrointest Oncol 2022; In press
Received
2022-01-15 22:43
Peer-Review Started
2022-01-15 22:43
To Make the First Decision
Return for Revision
2022-03-13 03:11
Revised
2022-03-19 22:57
Second Decision
2022-05-07 07:56
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-08 07:20
Articles in Press
2022-05-08 07:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Ya-Juan Ma
Reviewer Code 05531699, and 00054255
Editorial Director
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 75089_Auto_Edited-YJM.docx
Answering Reviewers 75089-Answering reviewers.pdf
Audio Core Tip 75089-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 75089-Conflict-of-interest statement.pdf
Copyright License Agreement 75089-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 75089-Language certificate.pdf
Peer-review Report 75089-Peer-review(s).pdf
Scientific Editor Work List 75089-Scientific editor work list.pdf