Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	75108
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian
Manuscript Source	Invited Manuscript
All Author List	Kaushik Chatterjee, Amit Kumar Dutta, Ashish Goel, Rekha Aaron, Vijayalekshmi Balakrishnan, Ajith Thomas, Anoop John, Rajeeb Jaleel, Deepu David, Reuben Thomas Kurien, SD Chowdhury, Ebby George Simon, AJ Joseph, Prasanna Premkumar and Anna B Pulimood
Funding Agency and Grant Number	Funding Agency Grant Number CMC Vellore FLUID grant 10360
Corresponding Author	Amit Kumar Dutta, MD, Professor, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Ground Floor, Williams Building, Vellore 632004, Tamil Nadu, India. akdutta1995@yahoo.co.in
Key Words	PTPN2 gene; Crohn’s disease; Genetic polymorphism; Case-control study; Asia; Risk factor
Core Tip	Several genetic risk factors have been associated with Crohn’s disease and they have provided valuable insights into the pathogenesis of the disease. However, some of the genetic changes are not observed uniformly across all populations and hence it is essential to determine their occurrence in different population. In this prospective case-control study, we have investigated the association of two common polymorphisms in PTPN2 gene (rs7234029 and rs2542151) with risk of Crohn’s Disease in an Asian country. Our results showed that contrary to observation form West, polymorphisms in PTPN2 gene were not associated with an increased risk of developing Crohn’s disease.
Citation	Chatterjee K, Dutta AK, Goel A, Aaron R, Balakrishnan V, Thomas A, John A, Jaleel R, David D, Kurien RT, Chowdhury S, Simon EG, Joseph A, Premkumar P, Pulimood AB. Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian. World J Gastrointest Pathophysiol 2022;13(4): 114-123

Received	2022-01-17 15:02
Peer-Review Started	2022-01-17 15:03
To Make the First Decision
Return for Revision	2022-03-10 11:44
Revised	2022-03-18 16:59
Second Decision	2022-05-18 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-23 00:48
Articles in Press	2022-05-23 00:48
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-13 09:23
Typeset the Manuscript	2022-06-01 09:26

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com