Publication Name	World Journal of Hepatology
Manuscript ID	75126
Country	Egypt

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection
Manuscript Source	Invited Manuscript
All Author List	Iman Ibrahim Salama, Hala M Raslan, Ghada A Abdel-Latif, Somaia I Salama, Samia M Sami, Fatma A Shaaban, Aida M Abdelmohsen and Walaa A Fouad
Funding Agency and Grant Number
Corresponding Author	Iman Ibrahim Salama, MD, Professor, Department of Community Medicine Research, National Research Center, El Tahrir Street-Doki-Giza_Egypt, Giza 12622, Dokki, Egypt. salamaiman@yahoo.com
Key Words	Hepatitis C virus; Hepatic; Extrahepatic; Direct-acting antivirals; Impact
Core Tip	Direct-acting antivirals (DAAs) are achieving an over 85% sustained virological response in treating hepatitis C virus (HCV) infection. The risk factors for DAAs failure include old males, cirrhosis, and the presence of resistance-associated substitutions mainly in genotypes 1a and 3. The higher rate of hepatocellular carcinoma after DAA therapy may be due to offering DAA regimens to patients with advanced liver fibrosis and cirrhosis, where using interferon was contraindicated. The change in the growth of pre-existing subclinical, undetectable hepatocellular carcinoma upon DAA treatment might be a cause. DAAs are effective in treating HCV-associated mixed cryoglobulinemia, thrombocytopenia, rheumatological, renal, and cardiovascular diseases.
Citation	Salama II, Raslan HM, Abdel-Latif GA, Salama SI, Sami SM, Shaaban FA, Abdelmohsen AM, Fouad WA. Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection. World J Hepatol 2022; 14(6): 1053-1073

Received	2022-01-17 01:48
Peer-Review Started	2022-01-17 01:49
To Make the First Decision
Return for Revision	2022-03-08 19:02
Revised	2022-04-01 09:01
Second Decision	2022-05-18 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-23 00:39
Articles in Press	2022-05-23 00:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-13 08:38
Typeset the Manuscript	2022-05-26 06:53

ISSN	1948-5182 (online)
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