Publication Name	World Journal of Clinical Cases
Manuscript ID	75182
Country	United States

Category	Endocrinology & Metabolism
Manuscript Type	Retrospective Study
Article Title	Hyperglycemia in COVID-19 infection without diabetes mellitus: Association with inflammatory markers
Manuscript Source	Invited Manuscript
All Author List	Harinivaas Shanmugavel Geetha, Garima Singh, Abinesh Sekar, Maya Gogtay, Yuvaraj Singh, GM Abraham and Nitin Trivedi
Funding Agency and Grant Number
Corresponding Author	Yuvaraj Singh, MD, Chief Physician, Researcher, Internal Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, MA 01608, United States. yuvarajmle@gmail.com
Key Words	COVID-19; Inflammatory markers; Hyperglycemia; C-reactive protein; Mortality; Severity; Mechanisms; Diabetes mellitus
Core Tip	Our study suggests that there is no correlation between the inflammatory marker levels and the presence of hyperglycemia in non-diabetic patients with coronavirus disease 2019 (COVID-19) infection. With an increased need to understand the mechanism underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-induced hyperglycemia, we assessed the validity of the most accepted COVID-19 infection-induced cytokine storm-related stress hyperglycemia theory. However, our study did not show any correlation between inflammatory marker levels that correlate with the cytokine storm and the level of hyperglycemia. This suggests the possibility of other mechanisms playing a role in the SARS-CoV-2 infection-induced hyperglycemia. Our study also demonstrated that new-onset hyperglycemia was an independent risk factor for higher mortality and length of stay, thereby emphasizing the need to understand the mechanisms leading to hyperglycemia.
Citation	Geetha HS, Singh G, Sekar A, Gogtay M, Singh Y, Abraham GM, Trivedi N. Hyperglycemia in COVID-19 infection without diabetes mellitus: Association with inflammatory markers. World J Clin Cases 2023; 11(6): 1287-1298

Received	2022-10-30 05:47
Peer-Review Started	2022-10-30 05:48
To Make the First Decision
Return for Revision	2022-11-28 04:46
Revised	2022-12-17 00:34
Second Decision	2023-02-03 03:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-03 07:09
Articles in Press	2023-02-03 07:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-01-13 01:32
Typeset the Manuscript	2023-02-14 15:14

ISSN	2307-8960 (online)
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