| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jihad Aljabban, Michael Rohr, Saad Syed, Eli Cohen, Naima Hashi, Sharjeel Syed, Kamal Khorfan, Hisham Aljabban, Vincent Borkowski, Michael Segal, Mohamed Mukhtar, Mohammed Mohammed, Emmanuel Boateng, Mary Nemer, Maryam Panahiazar, Dexter Hadley, Sajid Jalil and Khalid Mumtaz |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Jihad Aljabban, MD, MSc, Academic Research, Doctor, Department of Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, United States. jaljabban@uwhealth.org |
| Key Words |
Hepatitis B virus; Hepatocellular carcinoma; Genomics; Meta-analysis |
| Core Tip |
Hepatitis B virus (HBV) is a cause of hepatocellular carcinoma (HCC). Interestingly, this process is not necessarily mediated through cirrhosis and may in fact involve oncogenic processes. Prior studies have suggested specific oncogenic gene expression pathways were affected by viral regulatory proteins. Thus, identifying these genes and associated pathways could highlight predictive factors for HCC transformation, and has implications in early diagnosis and treatment. Our manuscript leverages big data to offer key insights to oncogenesis of HBV infection in HCC. We were able to dissect key genetic drivers to disease and namely demonstrate a newfound role for rab-like protein 6 and homeobox A10. |
| Citation |
Aljabban J, Rohr M, Syed S, Cohen E, Hashi N, Syed S, Khorfan K, Aljabban H, Borkowski V, Segal M, Mukhtar M, Mohammed M, Boateng E, Nemer M, Panahiazar M, Hadley D, Jalil S, Mumtaz K. Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data. World J Gastrointest Oncol 2022; 14(9): 1856-1873 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
