Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	75419
Country	United States

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Insight on BRAFV600E mutated colorectal cancer immune microenvironment
Manuscript Source	Invited Manuscript
All Author List	Hassan Mohammed Abushukair, Sara Mu'amar Zaitoun and Anwaar Saeed
Funding Agency and Grant Number
Corresponding Author	Anwaar Saeed, MD, N/A, Department of Medicine, Division of Medical Oncology, The University of Kansas Cancer Center, 2330 Shawnee Mission Pkwy, Suite 210, Kansas City, KS 66205, United States. asaeed@kumc.edu
Key Words	Colorectal cancer; BRAFV600E; Tumor microenvironment; Microsatellite instability; Macrophages; Immune checkpoint proteins
Core Tip	The immune landscape of the tumor microenvironment is a crucial indicator of the proliferative and invasive activity of the tumor cells and serves as a predictor of response to targeted immunotherapeutic modalities. BRAFV600E is one of the most common driver mutations in colorectal cancer thought to have a unique impact on the tumor immune microenvironment. It is unknown whether this impact is of a suppressive or activating nature. Future studies on larger samples, considering a wider array of immune elements, such as the infiltration of relevant immune cells as well as immune checkpoints’ expression, are needed.
Citation	Abushukair HM, Zaitoun SM, Saeed A. Insight on BRAFV600E mutated colorectal cancer immune microenvironment. World J Gastrointest Oncol 2022; 14(6): 1213-1215

Received	2022-01-27 12:12
Peer-Review Started	2022-01-27 12:14
To Make the First Decision
Return for Revision	2022-04-17 08:06
Revised	2022-05-04 12:40
Second Decision	2022-05-20 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-23 00:43
Articles in Press	2022-05-23 00:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-31 21:45

ISSN	1948-5204 (online)
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