Publication Name	World Journal of Gastroenterology
Manuscript ID	75427
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Colon mucus in colorectal neoplasia and beyond
Manuscript Source	Invited Manuscript
All Author List	Alexandre Loktionov
Funding Agency and Grant Number
Corresponding Author	Alexandre Loktionov, MD, PhD, Director, N/A, DiagNodus Ltd, St John’s Innovation Centre, Cowley Road, Cambridge CB4 0WS, United Kingdom. alex.loktionov@diagnodus.com
Key Words	Colon; Colon mucus; Mucins; Goblet cells; Gut microbiota; Inflammatory bowel disease; Colorectal cancer
Core Tip	Until recently colon mucus (CM) importance was largely ignored because its structure and functions were obscure. It is now known that human CM comprises a dense inner layer impenetrable for bacteria and a loose outer layer providing a habitat for abundant commensal microbiota. Mucus barrier integrity is essential for maintaining homeostatic balance between colonic mucosa and gut microbiota, and its impairment opens direct bacterial access to the epithelium, which induces inflammation and can cause severe disorders, including inflammatory bowel disease and colorectal cancer. Recent advances in colorectal mucus exploration and emerging new clinical applications based on this knowledge are discussed.
Citation	Loktionov A. Colon mucus in colorectal neoplasia and beyond. World J Gastroenterol 2022; 28(32): 4475-4492

Received	2022-01-27 16:13
Peer-Review Started	2022-01-27 16:15
To Make the First Decision
Return for Revision	2022-04-10 21:01
Revised	2022-04-23 14:30
Second Decision	2022-08-03 02:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-06 23:41
Articles in Press	2022-08-06 23:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-18 08:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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