Publication Name	World Journal of Clinical Cases
Manuscript ID	75605
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Ohkura, Hironori Uruga, Masato Shiiba, Shinji Ito, Hayato Shimoyama, Makiko Ishihara, Masaki Ueno and Harushi Udagawa
Funding Agency and Grant Number
Corresponding Author	Yu Ohkura, MD, PhD, Assistant Professor, Department of Gastroenterological Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Japan. jag.ptj69-or.jpajhq.107emtg@docomo.ne.jp
Key Words	Phosphoglyceride crystal deposition disease; Raman spectroscopy; Positron emission tomography; Foreign body granuloma with crystal deposition; Surgical scar; Case report
Core Tip	Here, we report a case in which Raman spectroscopy proved useful for differential diagnosis of phosphoglyceride crystal deposition disease (PCDD) in a patient with multiple malignant abdominal masses showing extremely high uptake on 18F-fluorodeoxyglucose positron emission tomography, many years after undergoing open splenectomy. Initially, we strongly suspected the masses to be malignant. To rule out malignancy, we performed surgical biopsies and the pathological diagnosis was foreign body granulomas with crystal deposition. Raman spectroscopy led to the definitive diagnosis of PCCD. Raman spectroscopy is a simple and precise method for diagnosing PCCD.
Citation	Ohkura Y, Uruga H, Shiiba M, Ito S, Shimoyama H, Ishihara M, Ueno M, Udagawa H. Phosphoglyceride crystal deposition disease requiring differential diagnosis from malignant tumors and confirmed by Raman spectroscopy: A case report. World J Clin Cases 2022; 10(23): 8304-8311

Received	2022-02-07 03:21
Peer-Review Started	2022-02-07 03:22
To Make the First Decision
Return for Revision	2022-04-11 02:06
Revised	2022-04-11 03:27
Second Decision	2022-06-29 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-30 18:48
Articles in Press	2022-06-30 18:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-13 02:27

ISSN	2307-8960 (online)
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