Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	76064
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Clinical implications of interleukins-31, 32, and 33 in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G Wise, Brett David Hambly, Kun Tao and Shi-San Bao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81502030
Corresponding Author	Shi-San Bao, MD, PhD, Academic Fellow, Department of Pathology, Tongren Hospital, No. 1111 Xianxia Road, Changning Distric, Shanghai 200336, China. bob.bao@sydney.edu.au
Key Words	Diagnosis and therapy; Gastric cancer; Immune cell interactions; Interleukin-31; Interleukin 32; Interleukin-33
Core Tip	Gastric cancer (GC) is one of the most common malignancies in China with a high morbidity and mortality. This study aimed to determine whether interleukin (IL)-31, IL-32, and IL-33 can be used as biomarkers for the detection of GC, via evaluating the correlations between their expression and clinicopathological parameters of GC patients. IL-31, IL-32, and IL-33 expression in GC was correlated with the severity of clinicopathological parameters. Circulating IL-33 was significantly low in GC patients. Our findings may provide new insights into the roles of IL-31, IL-32, and IL-33 in the carcinogenesis of GC.
Citation	Liu QH, Zhang JW, Xia L, Wise SG, Hambly BD, Tao K, Bao SS. Clinical implications of interleukins-31, 32, and 33 in gastric cancer. World J Gastrointest Oncol 2022; 14(9): 1808-1822

Received	2022-02-28 23:24
Peer-Review Started	2022-02-28 23:26
To Make the First Decision
Return for Revision	2022-04-17 04:50
Revised	2022-04-21 14:14
Second Decision	2022-07-29 02:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-01 04:09
Articles in Press	2022-08-01 04:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-07-25 10:50
Typeset the Manuscript	2022-08-31 07:56

ISSN	1948-5204 (online)
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