Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	76127
Country	China

Category	Anesthesiology
Manuscript Type	Randomized Controlled Trial
Article Title	Effect of cardiac output - guided hemodynamic management on acute lung injury in pediatric living donor liver transplantation
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Jing Dou, Qing-Ping Wang, Wei-Hua Liu, Yi-Qi Weng, Ying Sun and Wen-Li Yu
Funding Agency and Grant Number
Corresponding Author	Wen-Li Yu, Doctor, PhD, Chief Doctor, Department of Anesthesiology, Tianjin First Central Hospital, No. 24 Fukang Road, Tianjin 300192, China. yzxyuwenli@163.com
Key Words	Cardiac output; Hemodynamic management; Child; Liver transplantation; Acute lung injury; Reperfusion injury
Core Tip	This is the first randomized controlled trial to evaluate the effect of cardiac output (CO)-guided hemodynamic therapy in pediatric liver recipients. In this study, hemodynamic parameters, including CO, stroke volume index, stroke volume variation, and the maximum increase in the speed of intraventricular pressure (dp/dtmax) obtained through the pressure recording analytical method monitoring were used to guide intraoperative hemodynamic management. The incidence of postoperative acute liver injury was significantly lower in the interventional group. Moreover, the inflammatory factors (interleukin-6 and tumor necrosis factor-α), cardiac troponin I, and N-terminal pro-brain natriuretic peptide levels decreased faster in the intervention group.
Citation	Dou XJ, Wang QP, Liu WH, Weng YQ, Sun Y, Yu WL. Effect of cardiac output‐guided hemodynamic management on acute lung injury in pediatric living donor liver transplantation. World J Gastrointest Surg 2022; 14(9): 1037-1048

Received	2022-03-18 04:17
Peer-Review Started	2022-03-18 04:17
To Make the First Decision
Return for Revision	2022-05-12 03:13
Revised	2022-05-25 15:31
Second Decision	2022-08-08 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-18 00:24
Articles in Press	2022-08-18 00:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-19 13:38

ISSN	1948-9366 (online)
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