Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	76134
Country	United States

Category	Oncology
Manuscript Type	Frontier
Article Title	Gut microbiome and pancreatic cancer cachexia: An evolving relationship
Manuscript Source	Invited Manuscript
All Author List	Andrew Hendifar, Rasaq Akinsola, Hayato Muranaka, Arsen Osipov, Shant Thomassian, Natalie Moshayedi, Julianne Yang, Jonathan Jacobs, Suzanne Devkota, Neil Bhowmick and Jun Gong
Funding Agency and Grant Number	Funding Agency Grant Number UCLA Clinical and Translational Science Institute UL1TR001881 Award
Corresponding Author	Jun Gong, MD, Assistant Professor, Department of Medicine, Division of Hematology and Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AC 1042B, Los Angeles, CA 90048, United States. jun.gong@cshs.org
Key Words	Gut microbiome; Pancreatic cancer; Stool; Cachexia; Inflammation; Weight
Core Tip	Cachexia is a hallmark of pancreatic cancer and is characterized by muscle wasting, weight loss, and systemic inflammation. Despite advancements in nutritional support, pancreatic enzyme replacement therapy, and pharmacologic interventions for treating pancreatic cancer cachexia, it continues to have a significant negative impact on patient outcomes. We detail the results of a recent prospective clinical trial wherein cachectic patients with advanced pancreatic cancer achieved weight stability with 12 wk of enteral feeding. Notably, gut microbiome changes and an increased abundance of a specific microbe associated with enteral feeding highlight a potentially novel approach to mitigate cachexia through microbial modulation.
Citation	Hendifar A, Akinsola R, Muranaka H, Osipov A, Thomassian S, Moshayedi N, Yang J, Jacobs J, Devkota S, Bhowmick N, Gong J. Gut microbiome and pancreatic cancer cachexia: An evolving relationship. World J Gastrointest Oncol 2022; 14(7): 1218-1226

Received	2022-03-03 05:02
Peer-Review Started	2022-03-03 05:04
To Make the First Decision
Return for Revision	2022-04-17 04:36
Revised	2022-05-10 16:40
Second Decision	2022-06-13 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 20:37
Articles in Press	2022-06-20 20:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-02 07:32

ISSN	1948-5204 (online)
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