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6/20/2022 8:37:52 PM | Browse: 82 | Download: 27
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 76134
Country/Territory United States
Category Oncology
Manuscript Type Frontier
Article Title Gut microbiome and pancreatic cancer cachexia: An evolving relationship
Manuscript Source Invited Manuscript
All Author List Andrew Hendifar, Rasaq Akinsola, Hayato Muranaka, Arsen Osipov, Shant Thomassian, Natalie Moshayedi, Julianne Yang, Jonathan Jacobs, Suzanne Devkota, Neil Bhowmick and Jun Gong
Funding Agency and Grant Number
Funding Agency Grant Number
UCLA Clinical and Translational Science Institute UL1TR001881 Award
Corresponding Author Jun Gong, MD, Assistant Professor, Department of Medicine, Division of Hematology and Oncology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, AC 1042B, Los Angeles, CA 90048, United States. jun.gong@cshs.org
Key Words Gut microbiome; Pancreatic cancer; Stool; Cachexia; Inflammation; Weight
Core Tip Cachexia is a hallmark of pancreatic cancer and is characterized by muscle wasting, weight loss, and systemic inflammation. Despite advancements in nutritional support, pancreatic enzyme replacement therapy, and pharmacologic interventions for treating pancreatic cancer cachexia, it continues to have a significant negative impact on patient outcomes. We detail the results of a recent prospective clinical trial wherein cachectic patients with advanced pancreatic cancer achieved weight stability with 12 wk of enteral feeding. Notably, gut microbiome changes and an increased abundance of a specific microbe associated with enteral feeding highlight a potentially novel approach to mitigate cachexia through microbial modulation.
Citation Hendifar A, Akinsola R, Muranaka H, Osipov A, Thomassian S, Moshayedi N, Yang J, Jacobs J, Devkota S, Bhowmick N, Gong J. Gut microbiome and pancreatic cancer cachexia: An evolving relationship. World J Gastrointest Oncol 2022; In press
Received
2022-03-03 05:02
Peer-Review Started
2022-03-03 05:04
To Make the First Decision
Return for Revision
2022-04-17 04:36
Revised
2022-05-10 16:40
Second Decision
2022-06-13 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-20 20:37
Articles in Press
2022-06-20 20:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-02 07:32
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Chen-Chen Gao
Reviewer Code 05824934, and 03805255
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor Ying-Yi Yuan
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 76134_Auto_Edited_LM.docx
Answering Reviewers 76134-Answering reviewers.pdf
Audio Core Tip 76134-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 76134-Conflict-of-interest statement.pdf
Copyright License Agreement 76134-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 76134-Grant application form(s).pdf
Peer-review Report 76134-Peer-review(s).pdf
Scientific Misconduct Check 76134-Bing-Gao CC-2.png
Scientific Editor Work List 76134-Scientific editor work list.pdf