Publication Name	World Journal of Stem Cells
Manuscript ID	76207
Country	China

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Review
Article Title	Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications
Manuscript Source	Invited Manuscript
All Author List	Sheng-Meng Yuan, Xue-Ting Yang, Si-Yuan Zhang, Wei-Dong Tian and Bo Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China U21A20369 Sichuan Science and Technology Program 2021YJ0147 Research and Develop Program, West China Hospital of Stomatology Sichuan University RD-02-202113
Corresponding Author	Bo Yang, DDS, PhD, Academic Fellow, Chief Doctor, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Engineering Research Center of Oral Translational Medicine, National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section, Renmin South Road, Chengdu 610041, Sichuan Province, China. dr.yangbo@scu.edu.cn
Key Words	Dental pulp stem cells; Cell injections; Modified cells; Cell sheets; Cell spheroids; Regeneration
Core Tip	In this review, we aim to outline the present understanding of the potential application of dental pulp stem cells (DPSCs) and their derivatives in the field of regenerative medicine. DPSCs have different properties and regenerative potentials according to the age and health condition of the donor. For therapeutic applications, DPSCs can be administered through different methodologies, including by single injections and the transplantation of the cells and their derivatives with a support, as cell sheets or as cell spheroids. The underlying mechanisms of the regenerative potential of DPSCs and their derivatives may occur through direct regulation and immunomodulatory and paracrine effects.
Citation	Yuan SM, Yang XT, Zhang SY, Tian WD, Yang B. Therapeutic potential of dental pulp stem cells and their derivatives: Insights from basic research toward clinical applications. World J Stem Cells 2022; 14(7): 435-452

Received	2022-03-14 15:59
Peer-Review Started	2022-03-14 16:01
To Make the First Decision
Return for Revision	2022-05-11 06:56
Revised	2022-05-25 07:45
Second Decision	2022-06-13 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 22:19
Articles in Press	2022-06-20 22:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-22 00:08

ISSN	1948-0210 (online)
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