Publication Name	World Journal of Stem Cells
Manuscript ID	76727
Country	China

Category	Pediatrics
Manuscript Type	Basic Study
Article Title	Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells
Manuscript Source	Unsolicited Manuscript
All Author List	Ping Li, Yang Wang, Pei Li, Yuan-Lin Liu, Wei-Jiang Liu, Xiao-Yu Chen, Tian-Tian Tang, Ke-Min Qi and Yi Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China (to P.L.) 81602859 National Natural Science Foundation of China (to P.L.) 82173524 National Key Research and Development Program of China (to Y.Z.) 2016YFC1000305
Corresponding Author	Yi Zhang, MD, PhD, Professor, Department of Experimental Hematology and Biochemistry, Beijing Institute of Radiation Medicine, No. 27 Tai-ping Road, Beijing 100085, China. zhangyi612@hotmail.com
Key Words	Calcium; Obesity; Bone mesenchymal stem cells; Wnt/β-Catenin signaling pathway; Adipogenic differentiation; Male offspring
Core Tip	Maternal inappropriate dietary calcium intake during the pregnancy and lactation could aggravate the high-fat-diet-induced obesity with larger adipocytes, more serious inflammatory infiltration and higher serum metabolism indicators by disordering the expressions of related genes on the adipogenic differentiation in the adipose tissues among the male offspring. Meanwhile, it also showed the significantly different expressions of specific genes in the bone mesenchymal stem cells (BMSCs) to successfully polarize the adipogenic differentiation and suppress osteogenic differentiation in vivo and in vitro respectively. Furthermore, the related mechanistic insights were gained to worsen this differently adipogenic differentiation through the Wnt/β-Catenin signaling pathway both in the BMSCs and adulthood adipose tissues. The most worth mentioning of this study is that we have moved forward the preventive factors of the development of obesity such as the early-life appropriate calcium intake, which is not from the neonatal period, but from the period of maternal germ cells or fertilized egg formation.
Citation	Li P, Wang Y, Li P, Liu YL, Liu WJ, Chen XY, Tang TT, Qi KM, Zhang Y. Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells. World J Stem Cells 2022; 14(10): 756-776

Received	2022-05-05 02:00
Peer-Review Started	2022-05-05 02:03
To Make the First Decision
Return for Revision	2022-06-11 04:26
Revised	2022-06-24 05:13
Second Decision	2022-08-03 02:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-07 17:09
Articles in Press	2022-08-07 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-27 16:47
Typeset the Manuscript	2022-10-18 09:26

ISSN	1948-0210 (online)
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