Publication Name	World Journal of Hepatology
Manuscript ID	76739
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Hepatitis B virus markers in hepatitis B surface antigen negative patients with pancreatic cancer: Two case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Sergey Batskikh, Sergey Morozov and Dmitry Kostyushev
Funding Agency and Grant Number	Funding Agency Grant Number Moscow Department of Health AAAA-A18-118021590196-1 Ministry of Science and Higher Education FGMF-2022-0005 Russian Science Foundation 20-15-00373
Corresponding Author	Sergey Morozov, MD, PhD, Doctor, Senior Researcher, Department of Gastroenterology, Hepatology and Nutrition, Federal Research Center of Nutrition and Biotechnology, Kashirskoye Shosse 21, Moscow 115446, Russia. morosoffsv@mail.ru
Key Words	Pancreatic cancer; Pancreatic ductal adenocarcinoma; Hepatitis B virus; Previous hepatitis B; Anti-HBc; Hepatitis B virus X antigen
Core Tip	Hepatitis B virus (HBV) is a known carcinogen that may be involved in pancreatic cancer (PC) development. Detection of HBV biomarkers (especially - expression of HBx) within the tumor tissue may provide direct support for this. However, there is still a lack of such reports, particularly in non-endemic for HBV infection regions. In the report of case series, we present two cases of HBsAg-negative patients with pancreatic ductal adenocarcinoma, in whom the markers of HBV were detected in blood and in the tumor tissue. This reflects potential participation of the virus in the etiology and pathogenesis of pancreatic ductal adenocarcinoma.
Citation	Batskikh S, Morozov S, Kostyushev D. Hepatitis B virus markers in hepatitis B surface antigen negative patients with pancreatic cancer: Two case reports. World J Hepatol 2022; 14(7): 1512-1519

Received	2022-03-29 11:34
Peer-Review Started	2022-03-29 11:37
To Make the First Decision
Return for Revision	2022-05-12 08:28
Revised	2022-05-25 06:51
Second Decision	2022-06-27 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-27 17:03
Articles in Press	2022-06-27 17:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-22 01:39
Typeset the Manuscript	2022-07-01 01:47

ISSN	1948-5182 (online)
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