Publication Name	World Journal of Stem Cells
Manuscript ID	76783
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Na Dong, Pan-Pan Zhou, Dong Li, Hua-Su Zhu, Ling-Hong Liu, Hui-Xian Ma, Qing Shi and Xiu-Li Ju
Funding Agency and Grant Number	Funding Agency Grant Number Rongxiang Regenerative Medicine Foundation of Shandong University 2019SDRX-18 Clinical Practical New Technology Development Found of Qilu Hospital of Shandong University KYC 2019-0057 Clinical Research Center of Shandong University 2020SDUCRCA010 Natural Science Foundation of Shandong Province ZR2020MH063
Corresponding Author	Xiu-Li Ju, PhD, Chief Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com
Key Words	Mesenchymal stem cell; Hyperoxia; Multiple organ injury; Bronchopulmonary dysplasia; Heme oxygenase-1; JAK/STAT pathway
Core Tip	In the present study, we used a newborn rat model of postnatal hyperoxia exposure to simulate clinical bronchopulmonary dysplasia (BPD) and the associated heart and kidney injuries in preterm infants. Improved lung, heart, and kidney development, as well as reduced inflammatory and oxidative responses, were observed with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) administration. We demonstrated that hUC-MSCs ameliorate hyperoxia-induced systemic organ injuries by activating heme oxygenase-1 expression and JAK/STAT pathway. Overall, our study shows that intratracheal administration is a more attractive route of MSCs administration in preterm infants for the prevention and treatment of BPD and hyperoxia-induced systemic damage.
Citation	Dong N, Zhou PP, Li D, Zhu HS, Liu LH, Ma HX, Shi Q, Ju XL. Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways. World J Stem Cells 2022; 14(7): 556-576

Received	2022-03-30 14:40
Peer-Review Started	2022-03-30 14:42
To Make the First Decision
Return for Revision	2022-04-25 22:21
Revised	2022-05-04 08:42
Second Decision	2022-06-17 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 17:17
Articles in Press	2022-06-20 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-22 07:55

ISSN	1948-0210 (online)
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