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6/20/2022 5:17:26 PM | Browse: 48 | Download: 51
Publication Name World Journal of Stem Cells
Manuscript ID 76783
Country/Territory China
Category Cell Biology
Manuscript Type Basic Study
Article Title Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways
Manuscript Source Unsolicited Manuscript
All Author List Na Dong, Pan-Pan Zhou, Dong Li, Hua-Su Zhu, Ling-Hong Liu, Hui-Xian Ma, Qing Shi and Xiu-Li Ju
Funding Agency and Grant Number
Funding Agency Grant Number
Rongxiang Regenerative Medicine Foundation of Shandong University 2019SDRX-18
Clinical Practical New Technology Development Found of Qilu Hospital of Shandong University KYC 2019-0057
Clinical Research Center of Shandong University 2020SDUCRCA010
Natural Science Foundation of Shandong Province ZR2020MH063
Corresponding Author Xiu-Li Ju, PhD, Chief Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com
Key Words Mesenchymal stem cell; Hyperoxia; Multiple organ injury; Bronchopulmonary dysplasia; Heme oxygenase-1; JAK/STAT pathway
Core Tip In the present study, we used a newborn rat model of postnatal hyperoxia exposure to simulate clinical bronchopulmonary dysplasia (BPD) and the associated heart and kidney injuries in preterm infants. Improved lung, heart, and kidney development, as well as reduced inflammatory and oxidative responses, were observed with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) administration. We demonstrated that hUC-MSCs ameliorate hyperoxia-induced systemic organ injuries by activating heme oxygenase-1 expression and JAK/STAT pathway. Overall, our study shows that intratracheal administration is a more attractive route of MSCs administration in preterm infants for the prevention and treatment of BPD and hyperoxia-induced systemic damage.
Citation Dong N, Zhou PP, Li D, Zhu HS, Liu LH, Ma HX, Shi Q, Ju XL. Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways. World J Stem Cells 2022; In press
Received
2022-03-30 14:40
Peer-Review Started
2022-03-30 14:42
To Make the First Decision
Return for Revision
2022-04-25 22:21
Revised
2022-05-04 08:42
Second Decision
2022-06-17 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-06-20 17:17
Articles in Press
2022-06-20 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jia-Ru Fan
Reviewer Code 05818012, and 05817451
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 76783_Auto_Edited_LM.docx
Answering Reviewers 76783-Answering reviewers.pdf
Audio Core Tip 76783-Audio core tip.mp3
Biostatistics Review Certificate 76783-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76783-Conflict-of-interest statement.pdf
Copyright License Agreement 76783-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 76783-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 76783-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 76783-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 76783-Language certificate.pdf
Peer-review Report 76783-Peer-review(s).pdf
Scientific Misconduct Check 76783-Bing-Fan JR-2.png
Scientific Editor Work List 76783-Scientific editor work list.pdf