Publication Name	World Journal of Gastroenterology
Manuscript ID	76869
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Delayed immune-related sclerosing cholangitis after discontinuation of pembrolizumab: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Takeshi Tanaka, Arata Sakai, Masahiro Tsujimae, Yasutaka Yamada, Takashi Kobayashi, Atsuhiro Masuda and Yuzo Kodama
Funding Agency and Grant Number	Funding Agency Grant Number JSPS KAKENHI JP19K07938
Corresponding Author	Arata Sakai, PhD, Doctor, Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Hyogo, Japan. asakai@med.kobe-u.ac.jp
Key Words	Immune-related adverse events; Sclerosing cholangitis; Delayed immune-related events; Case report
Core Tip	Immune checkpoint inhibitors have become a new standard in cancer treatment, but have often been reported to induce adverse events, called immune-related adverse events (irAEs). Biliary system complications, such as irAEs, remain rare, and the management strategy remains unclear. We present herein, a rare case of delayed immune-related sclerosing cholangitis (SC) after discontinuation of pembrolizumab. Our case emphasizes that immune-related SC can occur later, but the mechanisms have not yet been elucidated. As such, our case contributes to new knowledge in the hopes of being able to establish proper diagnostic criteria and management strategies for similar patients.
Citation	Tanaka T, Sakai A, Tsujimae M, Yamada Y, Kobayashi T, Masuda A, Kodama Y. Delayed immune-related sclerosing cholangitis after discontinuation of pembrolizumab: A case report. World J Gastroenterol 2022; 28(28): 3732-3738

Received	2022-04-07 12:22
Peer-Review Started	2022-04-07 12:24
To Make the First Decision
Return for Revision	2022-05-09 06:12
Revised	2022-05-21 08:57
Second Decision	2022-06-29 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-30 22:27
Articles in Press	2022-06-30 22:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-07-01 06:30

ISSN	1007-9327 (print) and 2219-2840 (online)
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