Publication Name	World Journal of Clinical Cases
Manuscript ID	77103
Country	China

Category	Pediatrics
Manuscript Type	Case Report
Article Title	Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Zhu Lin, Qi-Ji Ma, Qi-Ming Pang, Qian-Dui Chen, Wan-Qi Wang, Jia-Yi Li and Su-Li Zhang
Funding Agency and Grant Number
Corresponding Author	Su-Li Zhang, MD, Doctor, Department of Neonatology, Hainan Women and Children's Medical Center, No. 15 Longkun Nan Road, Haikou 570100, Hainan Province, China. 18389454649@163.com
Key Words	Combined pituitary hormone deficiency; LHX3; Children; Gonadal dysplasia; Case report
Core Tip	We report an 11-yar-old boy with combined pituitary hormone deficiency (CPHD). DNA sequencing showed that there were two compound heterozygous variants in the LHX3 gene. This study extends the mutation spectrum of the LHX3 gene, and provides a molecular basis for the etiological diagnosis of CPHD and genetic consultation for the family.
Citation	Lin SZ, Ma QJ, Pang QM, Chen QD, Wang WQ, Li JY, Zhang SL. Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report. World J Clin Cases 2022; 10(31): 11486-11492

Received	2022-04-15 09:43
Peer-Review Started	2022-04-15 09:44
To Make the First Decision
Return for Revision	2022-07-14 08:11
Revised	2022-09-14 12:15
Second Decision	2022-09-29 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-29 10:37
Articles in Press	2022-09-29 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-12 02:11

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com