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Publication Name World Journal of Hepatology
Manuscript ID 77104
Country/Territory Belgium
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Real-life multi-center retrospective analysis on nivolumab in difficult-to-treat patients with advanced hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Nika De Wilde, Luisa Vonghia, Sven Francque, Thomas De Somer, Ali Bagdadi, Eva Staub, Jasper Lambrechts, Ana-Maria Bucalau, Gontran Verset and Christophe Van Steenkiste
Funding Agency and Grant Number
Corresponding Author Gontran Verset, MMed, Doctor, Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, Brussels 1070, Belgium. gontran.verset@erasme.ulb.ac.be
Key Words Advanced hepatocellular carcinoma; Systemic treatment; Immunotherapy; Nivolumab; Difficult-to-treat patients; Real-life setting
Core Tip We conducted a study on the real-world effectiveness of nivolumab (immunotherapy) in patients with advanced liver cancer who were ineligible for the standard of care or other validated treatments, including patients with impaired liver function and a poor general condition, a population that is usually not included in studies. We showed a reduction of tumor mass in 24.1% of patients, with a disappearance of tumor mass in 13.9% of patients, which is better than that reported in the literature. Furthermore, we confirmed the favorable safety profile of nivolumab. Hence, nivolumab should be considered as a valuable treatment option in selected patients who are otherwise not eligible for treatment.
Citation De Wilde N, Vonghia L, Francque S, De Somer T, Bagdadi A, Staub E, Lambrechts J, Bucalau AM, Verset G, Van Steenkiste C. Real-life multi-center retrospective analysis on nivolumab in difficult-to-treat patients with advanced hepatocellular carcinoma. World J Hepatol 2022; In press
Received
2022-04-15 13:24
Peer-Review Started
2022-04-15 13:25
To Make the First Decision
Return for Revision
2022-05-12 08:25
Revised
2022-05-27 14:15
Second Decision
2022-07-29 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-01 04:51
Articles in Press
2022-08-01 04:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-02 09:40
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Han Zhang
Reviewer Code 03372482, 03646555, and 03372482
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Production Editor Yi-Xuan Cai
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 77104_Auto_Edited-LM.docx
Answering Reviewers 77104-Answering reviewers.pdf
Audio Core Tip 77104-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 77104-Conflict-of-interest statement.pdf
Copyright License Agreement 77104-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 77104-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 77104-Language certificate.pdf
Supplementary Material 77104-Supplementary materials.pdf
Peer-review Report 77104-Peer-review(s).pdf
Scientific Editor Work List 77104-Scientific editor work list.pdf