Publication Name	World Journal of Diabetes
Manuscript ID	77453
Country	India

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Raja Chakraborty, Pobitra Borah, Partha Pratim Dutta and Saikat Sen
Funding Agency and Grant Number
Corresponding Author	Saikat Sen, PhD, Professor, Faculty of Pharmaceutical Science, Assam down town University, Gandhinagar, Panikhaiti, Guwahati 781026, Assam, India. saikat.pharm@rediffmail.com
Key Words	Diabetic Wound; Diabetic Foot Ulcer; Epigenetic mechanisms; Therapeutic agents; Molecular Targets; Phytoconstituents
Core Tip	This paper reviewed molecular pathways and epigenetic mechanisms involved in the pathogenesis of diabetic wounds. The role of microbiota, oxidative stress, inflammatory cytokines, and alteration in the factors involved in normal wound healing process was highlighted. Molecular targets of therapeutic agents, the role of phytochemicals was discussed. The efficacy of several pharmacotherapy, treatment strategies, and recent clinical trials aiming to improve the outcome of diabetic foot ulcers was reviewed.
Citation	Chakraborty R, Borah P, Dutta PP, Sen S. Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets. World J Diabetes 2022; 13(9): 696-716

Received	2022-05-01 06:34
Peer-Review Started	2022-05-01 06:35
To Make the First Decision
Return for Revision	2022-05-29 23:25
Revised	2022-06-12 18:17
Second Decision	2022-08-08 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-18 00:18
Articles in Press	2022-08-18 00:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-09-04 11:07

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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