Publication Name	World Journal of Gastroenterology
Manuscript ID	77470
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ellen S Wagner, Hussien Ahmed H Abdelgawad, Meghan Landry, Belal Asfour, Mark B Slidell and Ruba Azzam
Funding Agency and Grant Number
Corresponding Author	Ruba Azzam, MD, Associate Professor, Pediatric Gastroenterology, Hepatology, and Nutrition, The University of Chicago Medicine, Comer Children’ s Hospital, 5841 S Maryland Ave MC 4065, Chicago, IL 60637, United States. razzam@peds.bsd.uchicago.edu
Key Words	Biliary atresia; Cholestasis; Hepatic portoenterostomy; Fibrosis; Esophageal and gastric varices; Elasticity imaging techniques
Core Tip	Ultrasound elastography is an emerging, non-invasive imaging modality to detect organ stiffness. It may be a useful tool in biliary atresia (BA) diagnosis and post-Kasai fibrosis surveillance. In a meta-analysis of twenty existing studies (eleven for diagnosis and nine for follow-up), this paper shows that mean liver stiffness is significantly higher in BA patients compared to non-BA patients at time of diagnosis. Post-Kasai, elastography can differentiate between early and advanced fibrosis as well as help to discern the presence or absence of varices. While there are limitations to this analysis, elastography shows great promise for its utility as a non-invasive modality for BA patients.
Citation	Wagner ES, Abdelgawad HAH, Landry M, Asfour B, Slidell MB, Azzam R. Use of shear wave elastography for the diagnosis and follow-up of biliary atresia: A meta-analysis. World J Gastroenterol 2022; 28(32): 4726-4740

Received	2022-05-01 22:25
Peer-Review Started	2022-05-01 22:28
To Make the First Decision
Return for Revision	2022-06-19 05:25
Revised	2022-07-10 21:22
Second Decision	2022-07-29 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-01 03:13
Articles in Press	2022-08-01 03:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-17 00:28

ISSN	1007-9327 (print) and 2219-2840 (online)
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