Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	77473
Country	Brazil

Category	Oncology
Manuscript Type	Minireviews
Article Title	Oncologic aspects of the decision-making process for surgical approach for colorectal liver metastases progressing during chemotherapy
Manuscript Source	Invited Manuscript
All Author List	Raphael L C Araujo, Camila G C Y Carvalho, Carlos T Maeda, Jean Michel Milani, Diogo G Bugano, Pedro Henrique Z de Moraes and Marcelo M Linhares
Funding Agency and Grant Number
Corresponding Author	Raphael L C Araujo, MD, PhD, Adjunct Professor, Surgical Oncologist, Department of Surgery, Universidade Federal de São Paulo, Rua Napoleão de Barros, 715 Second Floor Vila Clementino, São Paulo 04024-002, Brazil. raphael.l.c.araujo@gmail.com
Key Words	Colorectal liver metastases; Oncology; Disease progression; Surgery; Liver resection; Hepatectomy
Core Tip	The mainstream curative-intent treatment of colorectal liver metastasis (CRLM) is complete surgical resection. Increasingly effective systemic chemotherapy has helped to improve long-term outcomes, downstaging of CRLM, and patient selection for surgery. Disease progression during chemotherapy represents an independent negative prognostic factor. However, in selected cases, based on size, the number of lesions, and tumor markers, surgery may be offered as an option for non-chemo responders. This minireview article aims to explore this open question in the literature using both evidence and meaningful thoughts on this controversial and challenging topic.
Citation	Araujo RLC, Carvalho CGCY, Maeda CT, Milani JM, Bugano DG, de Moraes PHZ, Linhares MM. Oncologic aspects of the decision-making process for surgical approach for colorectal liver metastases progressing during chemotherapy. World J Gastrointest Surg 2022; 14(9): 877-886

Received	2022-05-02 01:49
Peer-Review Started	2022-05-02 01:52
To Make the First Decision
Return for Revision	2022-07-14 18:46
Revised	2022-07-27 05:55
Second Decision	2022-08-08 03:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-18 00:22
Articles in Press	2022-08-18 00:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-19 13:52

ISSN	1948-9366 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com