Publication Name	World Journal of Hepatology
Manuscript ID	77971
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Bile acids as drivers and biomarkers of hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Santo Colosimo and Jeremy W Tomlinson
Funding Agency and Grant Number
Corresponding Author	Jeremy W Tomlinson, FRCP, PhD, Professor, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford OX3 7LE, United Kingdom. jeremy.tomlinson@ocdem.ox.ac.uk
Key Words	Bile acid; Liver cancer; Screening; Cirrhosis; Serum metabolites; Urine metabolites
Core Tip	The rapidly increasing prevalence of hepatocellular carcinoma (HCC) highlights the unmet clinical need to develop and enhance early diagnostic strategies. Evidence from rodent and in vitro models suggests that bile acids may have a crucial role in the pathogenesis of HCC. Changes in circulating bile acid profiles are observed in patients with HCC. Serum and urine bile acid profiles may predict HCC risk and may have potential as a non-invasive screening tool.
Citation	Colosimo S, Tomlinson J. Bile acids as drivers and biomarkers of hepatocellular carcinoma. World J Hepatol 2022;14(9): 1730-1738

Received	2022-05-30 13:56
Peer-Review Started	2022-05-30 14:00
To Make the First Decision
Return for Revision	2022-07-13 22:55
Revised	2022-07-18 10:05
Second Decision	2022-08-08 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-18 00:11
Articles in Press	2022-08-18 00:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-19 02:33

ISSN	1948-5182 (online)
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