Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	78357
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Xiao He, Hong Shen, Yu-Zhu Ji, Hai-Rong Hua, Yu Zhu, Xiang-Fei Zeng, Fang Wang and Kai-Xin Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81260361 Incubation Project of Mianyang Central Hospital 2020FH05
Corresponding Author	Kai-Xin Wang, MD, Associate Chief Physician, Department of Pathology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China. 313683968@qq.com
Key Words	N-myc downstream regulated gene 1; Caco2; Colorectal cancer; Tumor progression; CRISPR/Cas9; Lentivirus infection
Core Tip	This study investigated the molecular functions of N-myc downstream regulated gene 1 (NDRG1) in the process of colorectal cancer (CRC) migration through stable over-expression or knockout of NDRG1 in the Caco2 CRC cell line. Our results showed that NDRG1 over-expression arrested the cell cycle at the G1/S phase, while its knock-out significantly increased the number of G2 phase cells. Altogether, our results highlight the fact that NDRG1 inhibits tumor progression in Caco2 cells which may provide a novel diagnostic or therapeutic tool in inhibiting the migration of CRC.
Citation	He YX, Shen H, Ji YZ, Hua HR, Zhu Y, Zeng XF, Wang F, Wang KX. N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells. World J Gastrointest Oncol 2022; 2022; 14(12): 2313-2328

Received	2022-07-14 02:13
Peer-Review Started	2022-07-14 02:16
To Make the First Decision
Return for Revision	2022-09-26 09:21
Revised	2022-10-17 08:03
Second Decision	2022-11-23 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-11-23 06:57
Articles in Press	2022-11-23 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-11-10 21:43
Typeset the Manuscript	2022-12-05 04:31

ISSN	1948-5204 (online)
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