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Articles in Press
11/23/2022 6:57:50 AM | Browse: 12 | Download: 22
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 78357
Country/Territory China
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells
Manuscript Source Unsolicited Manuscript
All Author List Yi-Xiao He, Hong Shen, Yu-Zhu Ji, Hai-Rong Hua, Yu Zhu, Xiang-Fei Zeng, Fang Wang and Kai-Xin Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81260361
Incubation Project of Mianyang Central Hospital 2020FH05
Corresponding Author Kai-Xin Wang, MD, Associate Chief Physician, Department of Pathology, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), No. 89 Taoyuan Road, Nanshan District, Shenzhen 518052, Guangdong Province, China. 313683968@qq.com
Key Words N-myc downstream regulated gene 1; Caco2; Colorectal cancer; Tumor progression; CRISPR/Cas9; Lentivirus infection
Core Tip This study investigated the molecular functions of N-myc downstream regulated gene 1 (NDRG1) in the process of colorectal cancer (CRC) migration through stable over-expression or knockout of NDRG1 in the Caco2 CRC cell line. Our results showed that NDRG1 over-expression arrested the cell cycle at the G1/S phase, while its knock-out significantly increased the number of G2 phase cells. Altogether, our results highlight the fact that NDRG1 inhibits tumor progression in Caco2 cells which may provide a novel diagnostic or therapeutic tool in inhibiting the migration of CRC.
Citation He YX, Shen H, Ji YZ, Hua HR, Zhu Y, Zeng XF, Wang F, Wang KX. N-myc downstream regulated gene 1 inhibition of tumor progression in Caco2 cells. World J Gastrointest Oncol 2022; In press
Received
2022-07-14 02:13
Peer-Review Started
2022-07-14 02:16
To Make the First Decision
Return for Revision
2022-09-26 09:21
Revised
2022-10-17 08:03
Second Decision
2022-11-23 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-23 06:57
Articles in Press
2022-11-23 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-11-10 21:43
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Assistant Editor
Science Editor Jing-Jie Wang
Reviewer Code 03806663, and 05776275
Editorial Director
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor Donna Fox
Production Editor
Responsible Production Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 78357_Auto_Edited-LM.docx
Answering Reviewers 78357-Answering reviewers.pdf
Audio Core Tip 78357-Audio core tip.mp3
Biostatistics Review Certificate 78357-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 78357-Conflict-of-interest statement.pdf
Copyright License Agreement 78357-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 78357-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 78357-Language certificate.pdf
Peer-review Report 78357-Peer-review(s).pdf
Scientific Misconduct Check 78357-Bing-Wang JJ-2.png
Scientific Editor Work List 78357-Scientific editor work list.pdf