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9/29/2022 10:48:10 AM | Browse: 91 | Download: 260
Publication Name World Journal of Clinical Cases
Manuscript ID 78360
Country/Territory China
Category Oncology
Manuscript Type Clinical and Translational Research
Article Title Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment
Manuscript Source Unsolicited Manuscript
All Author List Ya-Ya Qin, Song Feng, Xiao-Dong Zhang and Bin Peng
Funding Agency and Grant Number
Funding Agency Grant Number
Nanchong City school science and technology strategic cooperation 20SXQT0304
Research and development project plan of Affiliated Hospital of North Sichuan Medical College 2020ZD003
Corresponding Author Bin Peng, MD, Professor, School of Basic Medicine, North Sichuan Medical College, No. 234 Fujiang Road, Shunqing District, Nanchong 637000, Sichuan Province, China. binpeng01@sina.com
Key Words Tumor; Ribonucleotide reductase M2 inhibitor; Traditional Chinese medicine; Monomer; Molecular docking; Literature mining
Core Tip Tumors seriously threaten human life and health. In our work, we found that ribonucleotide reductase M2 (RRM2) is highly expressed in most tumor tissues, and is related to poor prognosis. Seven traditional Chinese medicine monomers with good binding ability to RRM2 were identified, and their binding sites were summarized and analyzed. Those will provide ideas for the development of anti-tumor drugs with RRM2 inhibition in the future.
Citation Qin YY, Feng S, Zhang XD, Peng B. Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment. World J Clin Cases 2022; 10(31): 11299-11312
Received
2022-06-23 04:02
Peer-Review Started
2022-06-23 04:05
To Make the First Decision
Return for Revision
2022-09-05 02:22
Revised
2022-09-14 15:28
Second Decision
2022-09-29 03:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-09-29 10:48
Articles in Press
2022-09-29 10:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-10-17 14:13
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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