Publication Name	World Journal of Clinical Cases
Manuscript ID	78532
Country	China

Category	Orthopedics
Manuscript Type	Case Report
Article Title	Hemorrhagic shock due to ruptured lower limb vascular malformation in a neurofibromatosis type 1 patient: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ping Shen, Gang Jin, Rang-Teng Zhu and Han-Tao Jiang
Funding Agency and Grant Number
Corresponding Author	Han-Tao Jiang, MM, Attending Doctor, Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, No. 1 East Tongyang Road, Taizhou 318000, Zhejiang Province, China. jianght5652@enzemed.com
Key Words	Neurofibromatosis type 1; Vascular malformation; Hemorrhagic shock; Vascular embolization; Above-knee amputation; Case report
Core Tip	We present the case of a 47-year-old female with neurofibromatosis type 1 with a rupture of right lower limb arterial malformation. She presented with sudden right lower limb swelling for two hours and symptoms of hemorrhagic shock on admission. Computed tomography angiography showed right lower limb arteriovenous malformation, and the patient underwent emergency vascular embolization. However, the patient did not experience any improvement in hemorrhagic shock symptoms. As a result, the patient underwent right lower extremity above-knee amputation. After amputation, the patient's hemoglobin level improved significantly without blood transfusion, and she was discharged from the hospital after the incision healed.
Citation	Shen LP, Jin G, Zhu RT, Jiang HT. Hemorrhagic shock due to ruptured lower limb vascular malformation in a neurofibromatosis type 1 patient: A case report. World J Clin Cases 2022; 10(31): 11597-11606

Received	2022-07-01 14:54
Peer-Review Started	2022-07-01 14:56
To Make the First Decision
Return for Revision	2022-09-05 10:04
Revised	2022-09-15 16:07
Second Decision	2022-09-26 03:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-27 01:04
Articles in Press	2022-09-27 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-18 07:04

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	All the authors report no relevant conflicts of interest for this article.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com